Childhood autism: A complex disorder

doi:10.1016/0006-3223(86)90310-0

Biological Psychiatry

Volume 21, Issue 13, November 1986, Pages 1279-1290

https://doi.org/10.1016/0006-3223(86)90310-0 Get rights and content

Abstract

Twenty-four-hour urine samples from psychotic and autistic children were precipitated with benzoic acid at pH 4.3. Fractionation of the aromatic complexes thus formed with benzoic acid—protein and peptides and uric acid, proteins and peptides on G-25 columns—yielded filtration patterns that may be of diagnostic value. Peptide material could be extracted from the formed complexes and refractionated on P2 gels. Increased levels of peptide material, especially of N-substituted peptides, could be demonstrated. Several bioactive factors (Reichelt et al. 1981) are under study. Possible etiological factors are discussed, and a working hypothesis is presented.

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^☆: Supported in part by “Folkesanatoriet for nervøse” in Trondheim and the Research Fund for Retarded Children in Oslo.

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ArticleChildhood autism: A complex disorder☆

Abstract

Lancet

Brain Res

Biochem Biophys Res Commun

Pharmacol Res Commun

Neurosci Lett

Biochem Biophys Res Commun

Biol Psychiatry

J Biol Chem

Zur Ausscheidung von peptiden in menschlichen Harn

Hoppe Seyler Z Physiol Chem

Peptiduria in the Fanconi syndrome in peptide transport and hydrolysis

Die Psychopathologie des coeliakiekranken Kindes

Ann Pediatr

Regulation of degradation of thyrotropin releasing hormone by thyroid hormones

Nature

Urinary gonadotrophins and luteinizing hormone-releasing hormone (LHRH) like immunoreactivity during three normal reproductive cycles

Acta Endocrinol

A material with opioid activity in bovine milk and milk products

Naunyn-Schmiedebergs Arch Pharmacol

Enzymatic digestion of gliadin: The effect of the resultant peptides in adult coeliac disease

Clin Chim Acta

Calcium studies and their relationship to coeliac disease in autistic patients

Effect of anorexogenic peptide on gastric and pancreatic secretion

J Physiol (Lond)

More on coeliac disease as a model for schizophrenia

Biol Psychiatry

Effects of MIF-I and TRH on the brain

Infantile autism: A genetic study of 21 twin pairs

J Child Psychol Psychiatry

Evidence for, and implications of passage of intact peptides across the intestinal mucosa

Biochem Soc Trans

Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexes

J Autism Dev Disord

Peptidase inactivation of hypothalamic releasing hormone

Horm Res

Translocation of intracellular glutathione to membrane-bound glutamyltranspeptidase as a discrete step in the gamma-glutamyl cycle. Glutathionurea after inhibition of transpeptidase

Dermatomyositis: Urinary chromatographic finding by alkaline autoanalysis for peptides

Clin Chem

Article
Childhood autism: A complex disorder☆