Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Isolation and characterization of a novel glucuronosyl diacylglycerol from Mycobacterium smegmatis
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Cited by (26)
From the banal to the bizarre: Unravelling immune recognition and response to microbial lipids
2022, Chemical CommunicationsUnveiling the biodiversity of lipid species in Corynebacteria- characterization of the uncommon lipid families in C. glutamicum and pathogen C. striatum by mass spectrometry
2020, BiochimieCitation Excerpt :GlcA-DAG is a major lipid family found in the genus of pseudomonas and was the first anionic glycolipid found in gram-negative bacteria [19,20]. Wolucka and coworkers established the structures of GlcA-DAG found in Mycobacterium smegmatis using NMR and GC/MS and FAB mass spectrometry [21]. Both GlcA-DAG and Man-GlcA-DAG lipids were reported in C. glutamicum cells and the major species were falsely reported as GlcA 16:0/18:1-DAG and ManGlcA 16:0/18:1-DAG [11,13].
Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle
2016, Carbohydrate ResearchCitation Excerpt :This population of mouse NKT cells expressed an invariant Vα10-Jα50 TCR α-chain and retained the capacity to recognize CD1d-presented α-GalCer. Uniquely however, these cells were reactive to an α-glucuronosyl diacylglyceride, Gl-A, from Mycobacterium smegmatis.71 As in the case of the B. burdorferi and S. pneumoniae glycolipids, total synthesis of candidate structures was used to identify the precise structure of the natural material as that bearing (R)-tuberculostearic acid ((R)-10-methylstearic acid) at the sn-1 position and palmitic acid at the sn-2 position (Fig. 6).72
A bifunctional glycosyltransferase from agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation
2014, Journal of Biological ChemistryCitation Excerpt :There are only a few reports on GlcAD accumulating under phosphate deprivation as a surrogate for phospholipids (30, 31). Outside of Gram-negative bacteria, GlcAD or higher glycosylated forms exist only in a few other bacterial species (1, 32–34). The responsible GlcAD synthase in all these organisms have never been isolated.
Characterization of glucuronic acid containing glycolipid in Aspergillus fumigatus mycelium
2009, Carbohydrate ResearchCitation Excerpt :In A. fumigatus, since ugd1 mutant unable to synthetize the GlcA-DG does not present any phenotype, no biological function has been pointed. In Mycobacterium segmatis, glucuronate residue could be an antigen determinant.34 In contrast, ELISA experiments showed that GlcA-DG from A. fumigatus is not recognized by sera from aspergilloma patients (data not shown).
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis
2007, Journal of Biological ChemistryCitation Excerpt :The presence of the uronic acid residue in ManGlcAGroAc2 is interesting due to its rarity with regard to the published literature, especially with reference to Mycobacterium spp. In mycobacteria to date, a glucuronosyl diacylglycerol in Mycobacterium smegmatis (46), uronosyl-containing glycopeptidolipid in Mycobacterium avium (59–61), and a uronosyl-containing polar glycopeptidolipid in Mycobacterium habana (62) have been reported. This is the first description of its kind in Corynebacterianeae of a mannosylated variant of glucuronosyl diacylglycerol.