Biochimica et Biophysica Acta (BBA) - Biomembranes
Light-scattering properties of osmotically active liposomes
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Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity
2019, Biophysical JournalCitation Excerpt :Some studies invoke light-scattering theory to calculate the scattering properties of individual vesicles—their scattering cross section and efficiencies—to help tease apart these effects. Most studies use the Rayleigh-Gans-Debye approximation (17,18,21) in part because it has an analytical form and in part because many of these calculations were done before the availability of adequate computational power (23). Although the error in the calculated scattering efficiency can be as low as 1% for some vesicle sizes (24), the approximation breaks down when vesicles encapsulate materials that differ from the outside or when vesicles have multiple bilayers, otherwise known as multilamellar vesicles (Fig. 1 A).
Insights into accelerated liposomal release of topotecan in plasma monitored by a non-invasive fluorescence spectroscopic method
2015, Journal of Controlled ReleaseCitation Excerpt :Unfortunately, the correlation between these factors and nanoparticle efficacy remains largely unknown [2,3]. For liposomal formulations, bilayer integrity may be compromised by the particles' interactions with proteins (e.g. vesicle binding and particle opsonization) [4–7] or osmotic stresses [8,9] either in the circulation or at the tumor site. Actively-loaded liposomal formulations may also exhibit accelerated drug release due to in vivo factors that alter the intraliposomal pH [10].
Time evolution of monomers and aggregates of a polymethine dye probe the dynamics of model vesicles and micelles
2014, Journal of Photochemistry and Photobiology A: ChemistryCitation Excerpt :Spectral shifts confirm the probe incorporation into micelles. Solvatochromic shifts usually result mainly from bulk solution properties, such as the dielectric constant and refractive index [35], as in the case of polymethine dyes [36]. Red shifts thus reflect polarity differences, both on the dye ground and excited states and on changing from bulk water to the micelle microenvironment around the probe.
Optical characterization of liposomes by right angle light scattering and turbidity measurement
2000, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The total volume of liposomes was found to be reciprocally proportional to turbidity at 450 nm [15]. Based on the Mie theory, Yoshikawa et al. showed that turbidity is reciprocally proportional to the two-thirds power of the volume by treating multilamellar vesicles (MLV) as optically homogenous spheres with an average refractive index estimated by the volume fraction of lipid in the vesicle [16]. In an earlier study, Chong and Colbow calculated the specific 90° light scattering intensity and turbidity as a function of vesicle size and aqueous radius in the framework of the RGD theory [17].
Development of dried liposomes containing β-galactosidase for the digestion of lactose in milk
1999, International Journal of PharmaceuticsKinetics and role of α<inf>1</inf>-Acid glycoprotein-dependent osmotic transport of water and ions in Palmitoyl-L-oleoyl phosphatidylcholine liposomes
1997, International Journal of Biochemistry and Cell Biology