Role of cholesterol in membranes effects on phospholipid-protein interactions, membrane permeability and enzymatic activity
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2023, Journal of Drug Delivery Science and TechnologyDietary lipid quality mediates salt tolerance of a freshwater keystone herbivore
2021, Science of the Total EnvironmentCitation Excerpt :Cholesterol is the principal sterol in most animals, including Daphnia (Goad, 1981; Martin-Creuzburg et al., 2014). Incorporation of cholesterol into phospholipid bilayers has been shown to decrease the permeability of eukaryotic membranes to water and a variety of ions, including chloride (Finkelstein and Cass, 1967; Papahadjopoulos et al., 1973; Papahadjopoulos and Watkins, 1967), possibly by increasing the lateral packing of phospholipids (condensation effect) (de Meyer and Smit, 2009; Róg et al., 2009), thus reducing ion leakage through lipid bilayers (Haines, 2001). In contrast, water and ion permeability is expected to increase with the incorporation of PUFAs into membranes, because the double bonds cause a bending of the fatty acyl chains of phospholipids thus decreasing the lateral packing of phospholipid bilayers (Hazel and Williams, 1990; Manni et al., 2018).
Penetration of phospholipid membranes by poly-L-lysine depends on cholesterol and phospholipid composition
2020, Biochimica et Biophysica Acta - BiomembranesVertical order of DPPC multilayer enhanced by cholesterol-induced ripple-to-liquid ordered (LO) phase transition: Synchrotron X-ray reflectivity study
2017, Current Applied PhysicsCitation Excerpt :Among the important roles of cholesterol, its function in changing cell membrane structure is considered to be a key process in the formation of lipid rafts, which are tightly packed lipid-cholesterol complexes. These complexes serve as platforms for many important cellular processes, such as cell signaling, endocytosis and disease development [5–8]. Especially, lipid raft and associated cholesterol are known to have large correlation with neurodegenerative diseases like Alzheimer's [9–11].
Molecular simulation of nonfacilitated membrane permeation
2016, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Cholesterol is a major component of eukaryotic cell membranes and has a large effect on membrane permeability. Generally, solutes permeate membranes with higher cholesterol content at lower rates [94–96]. One of the earliest simulation studies on the effect of cholesterol content on membrane permeability was reported by Jedlovszky and Mezei [97].