Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family☆
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Cited by (82)
Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
2019, Archives of Biochemistry and BiophysicsCitation Excerpt :While CYP3A5 and CYP3A43 are primarily extrahepatic enzymes, they also exist in the liver, but at lower levels (10–30% of total CYP content) [10,18] and only 0.2–5% [16] that of CYP3A4, respectively. CYP3A7 is found predominantly in human fetal livers and presents in embryonic hepatic tissues as early as 50–60 days of gestation [11,19–22], accounting for up to 50% of the total fetal hepatic CYP content and up to 87–100% of total fetal hepatic CYP3A content [23–26]. However, its expression has also been reported in other fetal tissue types, including the adrenal gland, kidney and lung [27].
Cytochrome P450 CYP3A in marsupials: Cloning and identification of the first CYP3A subfamily member, isoform 3A70 from Eastern gray kangaroo (Macropus giganteus)
2012, GeneCitation Excerpt :The CYP3A immunoreactive band observed in kangaroo and wallaby microsomes appeared to comprise more than two bands, although all were not apparently distinct, which suggested the presence of multiple CYP3A isoforms in the liver of these marsupials. This is consistent with that reported previously for humans (Strausberg et al., 2002; Westlind et al., 2001; Wrighton and Vandenbranden, 1989) and other species such as rats (Matsubara et al., 2004; Wang et al., 1996), mice (Sakuma, 2000; Sakuma et al., 2000), and canine (Fraser et al., 1997). The two distinct CYP3A bands detected in kangaroo and wallaby were of approximately 59 and 50 kDa, those detected in wombat, koala, and rat were of approximately 58 kDa.
Cytochrome P450 CYP3A in marsupials: Cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus)
2011, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :The CYP3A immunoreactive band observed in kangaroo and tammar wallaby microsomes appeared to comprise more than two bands, although all were not apparently distinct, which suggested the presence of multiple CYP3A isoforms in the liver of these marsupials. This is consistent with that reported previously for humans (Wrighton and Vandenbranden, 1989; Westlind et al., 2001; Strausberg et al., 2002) and other species such as rats (Wang et al., 1996; Matsubara et al., 2004), mice (Sakuma, 2000; Sakuma et al., 2000), and canine (Fraser et al., 1997). The two distinct CYP3A bands detected in kangaroo and tammar wallaby were of approximately 59 and 50 kDa, those detected in wombat, koala, and rat were of approximately 58 kDa.
Expression and induction of CYP3As in human fetal hepatocytes
2004, Biochemical and Biophysical Research Communications
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This research was supported by a grant from the National Institutes of Health (GM-37498).