Further studies on the role of bile salts in cholesterol esterification and absorption from the gut☆,☆☆
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Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice
2019, Journal of Lipid ResearchCitation Excerpt :Together, these findings indicate that the abrogated intestinal cholesterol absorption in Asbt−/− mice primarily resulted from strongly reduced biliary BA secretion. Apparently, the decreased biliary BA secretion could not be compensated for by a more hydrophobic BA composition, despite the notion that hydrophobic BAs are more effective in aiding the micellar solubilization and subsequent absorption of cholesterol (40, 42). Theoretically, the decreased cholesterol absorption in Asbt−/− mice could be due to the downregulation of Npc1l1 expression in the duodenum, but the unaffected steady-state mRNA levels did not support this possibility (Fig. 5A).
Meta-analysis of the influence of dietary glycine and serine, with consideration of methionine and cysteine, on growth and feed conversion of broilers
2015, Poultry ScienceCitation Excerpt :Furthermore, one molecule of Ser is required to synthesize one molecule of cysteine (Cys) from one molecule of methionine (Met) when L-homocysteine is metabolized to L,L-cystathione (Braunstein et al., 1969; Velíšek and Cejpek, 2006). Other metabolic pathways that require Gly or Ser are the synthesis of glutathione (Bartlett et al., 1956) and creatine (Bloch and Schoenheimer, 1940), bile activity (Gallo-Torres et al., 1971), and protein synthesis in the liver (Ngo et al., 1977). Numerous studies, in particular those investigating reduced-protein diets, have observed the performance-enhancing effects of Gly supplementation (e.g., Corzo et al., 2004; Dean et al., 2006; Jiang et al., 2005).
From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons
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This work includes material from a thesis submitted by Hugo E. Gallo-Torres to the Graduate School of Tulane University in partial fulfillment of the requirements for the degree of Doctor of Philosophy. The research was supported by Grants-in-Aid TIAM 5369 and H 4150 from the National Institutes of Health, Bethesda, Maryland, and by a Grant from Hoffmann-La Roche Inc., Nutley, New Jersey.
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Part of this work was presented at the Eighth International Congress of Nutrition, Prague, September 1969.
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Present address: Department of Vitamin and Nutritional Research, Hoffmann-La Roche & Co., Basle, Switzerland.
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Present address: Department of Biochemical Nutrition, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.