Aprotinin in children undergoing repair of congenital heart defects
References (13)
- et al.
Comparison of the hemostatic effects of fresh whole blood stored whole blood and components after open heart surgery in children
Blood
(1991) - et al.
Coagulation defects in neonates during cardiopulmonary bypass
Ann Thorac Surg
(1992) - et al.
Complement and the damaging effects of cardiopulmonary bypass
J Thorac Cardiovasc Surg
(1983) - et al.
Aprotinin in children undergoing correction of congenital defects
J Thorac Cardiovasc Surg
(1994) - et al.
Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centres in the United Kingdom
Ann Thorac Surg
(1993) - et al.
Aprotinin improves myocardial recovery after ischemia and reperfusion
J Thorac Cardiovasc Surg
(1994)
Cited by (32)
Anesthesia for Pediatric Cardiac Surgery
2006, Critical Heart Disease in Infants and ChildrenVariability of plasma aprotinin concentrations in pediatric patients undergoing cardiac surgery
2004, Journal of Thoracic and Cardiovascular SurgeryHemispheric Infarction in a Patient with an Undiagnosed Vasculopathy Treated with Aprotinin
2004, Journal of Cardiothoracic and Vascular AnesthesiaAprotinin reduces operative closure time and blood product use after pediatric bypass
2003, Annals of Thoracic SurgeryCitation Excerpt :In a prospective, randomized, double-blind, placebo-controlled study limited to pediatric patients having a repeat sternotomy, D’Errico and associates found that the use of aprotinin was cost effective and resulted in a dose-dependent reduction in the administration of packed red blood cells, platelets, and fresh-frozen plasma during the first 24 postoperative hours [22]. Penkoske and associates reported in a retrospective, case control study of 80 pediatric patients and 55 controls at higher risk for bleeding, most of whom had a repeat sternotomy, that low-dose aprotinin was effective for reducing operative closure time, transfusion requirements, and donor exposure [23]. However, an increased rate of thrombosis and mediastinitis were noted in the aprotinin group, complications not noted in our patient population.
Coagulation abnormalities in patients with cyanotic congenital heart disease
2002, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Aprotinin also has some disadvantages. Besides being expensive, it has been suggested that aprotinin may promote thrombus formation,71,90 lead to severe hemodynamic instability,91 and cause impairment in renal function.77 The risk of anaphylaxis, although small, is real, similar to any other polypeptide.
Con: The routine use of aprotinin during pediatric cardiac surgery is not a benefit
1999, Journal of Cardiothoracic and Vascular Anesthesia