Original communicationOxytocin and milk ejection
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Cited by (23)
Oxytocin preprotein and oxytocin receptor mRNA expression is altered in semen samples with abnormal semen parameters
2023, Reproductive BioMedicine OnlineCitation Excerpt :It acts mainly through the oxytocin receptor (OTR), a seven transmembrane-domain polypeptide belonging to the rhodopsin-type class 1 G-protein coupled receptor family (Kimura et al., 1992). Oxytocin was initially characterized as a ‘female’ hormone owing to its crucial role in parturition (Dale, 1906), milk ejection during lactation (Nickerson et al., 1954) and sexual activity (Anderson-Hunt and Dennerstein, 1995). It is now well established, however, that oxytocin has both endocrine and paracrine effects in the female and male reproductive system and behaviour.
Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala
2021, NeuropharmacologyCitation Excerpt :Oxytocin (OT) is a nine amino acid peptide serving as a hypothalamic hormone, which regulates uterine contractions during labor, milk ejection reflex during lactation (Caldeyro-Barcia and Poseiro, 1959; Nickerson et al., 1954), as well as water-electrolyte balance (Han et al., 1993; Verbalis et al., 1993).
Oxytocin during breastfeeding and maternal mood symptoms
2020, PsychoneuroendocrinologyCitation Excerpt :Lower levels of oxytocin, a neuropeptide involved in social behavior, have been shown to be associated with higher levels of depression in both non-pregnant adults (Gordon, Zagoory-Sharon et al. 2008) and postpartum women (Skrundz, Bolten et al. 2011). Oxytocin is critical for the milk ejection reflex to occur (Ely and Petersen, 1941; Gunther, 1942; Nickerson, Bonsnes et al. 1954). The relationship between oxytocin, maternal mood symptoms, and breastfeeding is not well understood.
Prosocial effects of prolactin in male rats: Social recognition, social approach and social learning
2017, Hormones and BehaviorCitation Excerpt :PRL promotes milk synthesis (Koprowski and Tucker, 1973), and its release from the anterior pituitary is regulated by tonic dopamine inhibition [reviewed in Ben-Jonathan and Hnasko, 2001]. OT is released from the posterior pituitary to control milk let-down (Nickerson et al., 1954). Although lactation is limited to females, PRL and OT also function as neuromodulators in both males and females.
Autism, oxytocin and interoception
2014, Neuroscience and Biobehavioral ReviewsOxytocin and bone remodelling: Relationships with neuropituitary hormones, bone status and body composition
2011, Joint Bone SpineCitation Excerpt :Although it can be synthesized in a few peripheral tissues, including the heart and reproductive systems, oxytocin (OT) is predominantly produced by magnocellular neurones and is translated from the most prevalent hypothalamic-specific mRNA [3]. OT is involved in several central and peripheral functions including parturition, milk letdown reflex and social behaviour [3–5]. Like leptin, OT plays a major role in the regulation of food intake and OT−/− mice develop late-onset obesity [6–10].