Abstract
The polymorphic microbiome has been defined as one of the “Hallmarks of Cancer”. Extensive studies have now uncovered the role of oral microbiota in cancer development and progression. Bacteria, fungi, archaea, and viruses in the oral cavity interact dynamically with the oral microenvironment to maintain the oral micro-ecological homeostasis. This complex interaction is influenced by many factors, such as maternal transmission, personal factors and environmental factors. Dysbiosis of oral microbiota can disturbed this host–microbiota interaction, leading to systemic diseases. Numerous studies have shown the potential associations between oral microbiota and a variety of cancers. However, the underlying mechanisms and therapeutic insights are still poorly understood. In this review, we mainly focus on the following aspects: (1) the factors affect oral microbiota composition and function; (2) the interaction between microenvironment and oral microbiota; (3) the role of multi-kingdom oral microbiota in human health; (4) the potential underlying mechanisms and therapeutic benefits of oral microbiota against cancer. Finally, we aim to describe the impact of oral microbiota on cancer progression and provide novel therapeutic insights into cancer prevention and treatment by targeting oral microbiota.
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Abbreviations
- Bad:
-
Bcl-2-associated death promoter
- BAX:
-
Bcl-2-associated X
- BRAF :
-
B-Raf proto-oncogene
- C. albicans :
-
Candida albicans
- CCA:
-
Constrained correspondence analysis
- CDK:
-
Cyclin-dependent kinase
- CH3SH:
-
Methyl mercaptan
- COX:
-
Cyclooxygenase
- CRA:
-
Colorectal adenoma
- CRC:
-
Colorectal cancer
- E2F:
-
E2 factor
- EPS:
-
Extracellular polymeric substances
- FadA:
-
Fusobacterium nucleatum Adhesin A
- F. nucleatum :
-
Fusobacterium nucleatum
- HMP:
-
Human Microbiome Project
- HPV:
-
Human papillomavirus
- hRAS :
-
HRas proto-oncogene
- H2S:
-
Hydrogen sulfide
- JAK1:
-
Janus kinase 1
- KRAS:
-
Kirsten rat sarcoma virus
- LPS:
-
Lipopolysaccharide
- MAMPs:
-
Microbe-associated molecular patterns
- MMP:
-
Matrix metalloproteinase
- mTOR :
-
Mechanistic target of rapamycin kinase
- MYC :
-
MYC proto-oncogene
- NK:
-
Natural killer
- OSCC:
-
Oral squamous cell carcinoma
- P. gingivalis :
-
Porphyromonas gingivalis
- PI3K:
-
Phosphoinositide 3-kinase
- PI3KCA :
-
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
- PRRs:
-
Pattern recognition receptors
- rRNA:
-
Ribosomal RNA
- S. aureus :
-
Staphylococcus aureus
- S. epidermidis :
-
Staphylococcus epidermidis
- STAT3:
-
Signal transducer and activator of transcription 3
- Streptococcus sp.:
-
Streptococcus Species
- TIGIT:
-
T cell immunoglobulin and ITIM domain
- TLRs:
-
Toll-like receptors
- VSCs:
-
Volatile sulfur compounds
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Acknowledgements
This work was supported by MOST Key R&D Program of China (2022YFC2304703), National Natural Science Foundation of China (32270202), Innovative research team of high-level local universities in Shanghai. The authors are thankful for the support from all lab members in Liu Lab (Fun Guy Group) in Shanghai Jiao Tong University School of Medicine.
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NL conceived and designed the manuscript. XW and HX wrote the manuscript and drafted the figures and tables. NL revised the manuscript. All authors have read and approved the final manuscript.
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Wang, XL., Xu, HW. & Liu, NN. Oral Microbiota: A New Insight into Cancer Progression, Diagnosis and Treatment. Phenomics 3, 535–547 (2023). https://doi.org/10.1007/s43657-023-00124-y
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DOI: https://doi.org/10.1007/s43657-023-00124-y