Abstract
The high prevalence of age-related diseases among the population explosion of senior citizens has gained significance in the pursuit of therapeutic agents capable of slowing the progression of degenerative disorders and preventing premature aging. Since our societies’ rising longevity is correlated with an increase in morbidity, preserving health in old age has become the main objective for biomedicine. Natural antioxidants are increasingly used as healthy ingredients in the nutrition, cosmetics, and pharmaceutical industries. Some synthetic drugs used as health supplements are enzyme inhibitors mediating several disease processes. However, due to concerns regarding their toxicity and adverse effects, several newly discovered heterogeneous phenolic and biphenolic structures have sparked a search for novel, safe, and effective agents, especially from natural sources. Natural antioxidants are one of the most well-studied natural product groups due to the wide range of biological effects they have. This review summarizes current knowledge on the various antioxidants and their action against age-related diseases like rheumatoid arthritis, skin aging, eye degeneration, metabolic syndrome, and neuroinflammation. According to our study, a wide variety of antioxidants have been examined, and although some potential therapeutic molecules have been identified based on their antioxidant action, further in vivo studies and evaluation are needed before a possible therapeutic implementation as drug candidates.
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The first author thanks the Chandigarh University for providing the infrastructure to carry out the research work.
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AD and ZAK both conceived and designed the review paper. AD and VD contributed to the paper realization.
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Devi, A., Dwibedi, V. & Khan, Z.A. Natural Antioxidants in New Age-Related Diseases. Rev. Bras. Farmacogn. 31, 387–407 (2021). https://doi.org/10.1007/s43450-021-00175-0
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DOI: https://doi.org/10.1007/s43450-021-00175-0