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The Elusiveness of the Win Ratio Parameter in the Presence of Missing Data

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References

  1. Pocock SJ, Ariti CA, Collier TJ, et al. The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities. Eur Heart J. 2012;33:176–82.

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  4. Food US, Administration D, E9(R1.) Statistical Principles for Clinical Trials: Addendum: Estimands and Sensitivity Analysis in Clinical Trials, https://www.fda.gov/regulatory-information/search-fda-guidance-documents/e9r1-statistical-principles-clinical-trials-addendum-estimands-and-sensitivity-analysis-clinical.

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Authors and Affiliations

  1. Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD-20993, USA

    Heng Li, Wei-Chen Chen, Nelson Lu, Rong Tang & Yu Zhao

Authors
  1. Heng Li
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  2. Wei-Chen Chen
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  3. Nelson Lu
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  4. Rong Tang
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  5. Yu Zhao
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Contributions

HL conceived of the paper and wrote the first draft. WCC did the computation and contributed to the development and preparation of the article. NL, RT and YZ contributed to the development and preparation of the article. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Rong Tang.

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Conflict of Interest

There are no financial interests in relation to the work described.

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Li, H., Chen, WC., Lu, N. et al. The Elusiveness of the Win Ratio Parameter in the Presence of Missing Data. Ther Innov Regul Sci 58, 431–432 (2024). https://doi.org/10.1007/s43441-024-00645-2

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  • DOI: https://doi.org/10.1007/s43441-024-00645-2

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