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Biorefining of essential polyunsaturated fatty acids from microbial sources: current updates and prospects

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A Correction to this article was published on 07 November 2023

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Abstract

The biorefinery approach ensures a sustainable source of valuable fatty acids and opens up new avenues for their application in healthcare industries. Recent studies highlight the health benefits of omega-PUFAs, spurring the search for cost-effective production methods. Microbial platforms are promising for high-yield PUFA production, with ω-3 dominating the market. ω-3 PUFAs offer antioxidant and anti-inflammatory effects, reducing illness risk, while all PUFAs contribute to cardiovascular health, diabetes prevention, cancer risk reduction, and more. ω-6 PUFAs, particularly linoleic acid (LA) and arachidonic acid (ARA), play vital roles in various aspects of health, making them high-demand bioavailable compounds. Additionally, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) exhibit potential benefits in brain development and COVID-19 prevention. This comprehensive review provides insights into the state-of-the-art microbial biorefinery strategies for ω-3 and ω-6 PUFA production and their wide-ranging health-related benefits.

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Acknowledgements

The author acknowledges the Ph.D. program of the Institute of Aquatic Science and Technology, College of Hydrosphere, National Kaohsiung University and Science and Technology.

Funding

RRS acknowledges NSTC, Taiwan, for funding support (Ref. No. NSTC 112-2222-E-992-006-MY2) and the National Kaohsiung University of Science and Technology 112 Annual Marine Characteristics Sustainable Development Research Program (Program code 112A14).

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Author notes

  1. Ajeet Singh Chauhan and Anil Kumar Patel equally contributed.

Authors and Affiliations

  1. Institute of Aquatic Science and Technology, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung City, 81157, Taiwan

    Ajeet Singh Chauhan, Anil Kumar Patel, Vanshika Nimker, Reeta Rani Singhania, Chiu-Wen Chen & Cheng-Di Dong

  2. Centre for Energy and Environmental Sustainability, Lucknow, Uttar Pradesh, 226 029, India

    Anil Kumar Patel & Reeta Rani Singhania

  3. Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India

    Vanshika Nimker

  4. Department of Marine Environmental Engineering, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung City, 81157, Taiwan

    Chiu-Wen Chen & Cheng-Di Dong

  5. Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental, and Natural Resources Engineering, Luleå University of Technology, 971 87, Luleå, Sweden

    Alok Kumar Patel

  6. Department of Agricultural and Biological Engineering, University of Illinois Urbana-Champaign, 1304 West Pennsylvania Avenue, Urbana, IL, 61801, USA

    Tirath Raj

Authors
  1. Ajeet Singh Chauhan
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  2. Anil Kumar Patel
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  4. Reeta Rani Singhania
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  7. Tirath Raj
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  8. Cheng-Di Dong
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Contributions

ASC: writing—original draft, literature review; AKP: supervision, writing—review and editing; VN: literature review, draft preparation; RRS: supervision, writing—review and editing, funding acquisition; C-WC: supervision, writing—review, and editing; AKP: literature review, draft preparation; supervision; TR: literature review, draft preparation; C-DD: supervision, writing—review and editing.

Corresponding authors

Correspondence to Reeta Rani Singhania or Cheng-Di Dong.

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Additional information

In this article the affiliation details for Author Tirath Raj were incorrectly given as Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), University of Illinois Urbana Champaign, AESB, 1304 West Pennsylvania Avenue I, Urbana, IL 61801, USA but should have been Department of Agricultural and Biological Engineering, University of Illinois Urbana-Champaign, 1304 West Pennsylvania Avenue, Urbana, IL, 61801, USA.

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Chauhan, A.S., Patel, A.K., Nimker, V. et al. Biorefining of essential polyunsaturated fatty acids from microbial sources: current updates and prospects. Syst Microbiol and Biomanuf 4, 425–447 (2024). https://doi.org/10.1007/s43393-023-00207-x

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