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Umbilical Cord Blood-Derived Exosomes in Maternal–Fetal Disease: a Review

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Abstract

The nutrients and other factors transported by umbilical cord blood, which is vital for fetal survival, play crucial roles in fetal development. There are various communication modes between the fetal-placental system and the maternal-placental system, and these communication modes are all mediated by umbilical cord blood. During the process of umbilical cord blood transportation, the changes of some nutrients and factors may play a key role in fetal development. Exosomes, which are members of the extracellular vesicle family, are present in the umbilical cord blood and play roles in information transmission as a result of their efficient cellular communication activity. The study of umbilical cord blood-derived exosomes provides a new approach for research on the etiology of maternal–fetal diseases and they may be useful for the development of intrauterine treatments. This review summarizes specific functions and research directions regarding umbilical cord blood-derived exosomes, and their potential associations with pregnancy complications.

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Data Availability

The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study was funded by the Natural Science Foundation of China (No. 81300492) and prenatal diagnosis, intrauterine intervention, and prognosis evaluation of complicated twins (No. 2018YFC1002902).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

    Jingyi Liu, Caixia Liu & Quan Na

  2. Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China

    Wei Sun

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  1. Jingyi Liu
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  2. Wei Sun
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  3. Caixia Liu
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  4. Quan Na
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Contributions

Conception and design: Jingyi Liu and Quan Na

Administrative support: Jingyi Liu and Wei Sun

Provision of study materials or patients: Jingyi Liu and Caixia Liu

Collection and assembly of data: Quan Na and Caixia Liu

Data analysis and interpretation: Wei Sun and Quan Na

Manuscript writing: all authors

Final approval of manuscript: all authors

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Correspondence to Quan Na.

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Liu, J., Sun, W., Liu, C. et al. Umbilical Cord Blood-Derived Exosomes in Maternal–Fetal Disease: a Review. Reprod. Sci. 30, 54–61 (2023). https://doi.org/10.1007/s43032-022-00879-1

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