Abstract
Recently, human iPS cells derived cardiomyocytes (hiPS-CM) have been utilized as the power source of biological actuators. However, the detailed mechanical properties of hiPS-CM have not been well understood yet. The primary aim of this study was to characterize and compare the stress–strain responses of two-dimensional hiPS-CM sheet and three-dimensional tube structure under self-contractive deformation. Firstly, their pulsation behaviors were examined as the time variation of brightness using a high-speed imaging system. Then, the minimum principal strain values on the surfaces of the sheet and tube were measured using the digital correlation method with the consecutive digital images. The theoretical strain was fund to coincide with the experimental strain vey well, indicating the validity of the developed theoretical models. The stress–strain responses of the sheet and tube were then constructed using the active stress model and the experimental strain. It was found that both the stress–strain responses clearly exhibited viscoelastic behaviors characterized by the hysteresis loop. It was thus concluded that the mechanical responses of hiPS-CM structures could be characterized using the viscoelastic theory along with the active stress model.
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Change history
14 December 2022
A Correction to this paper has been published: https://doi.org/10.1007/s42558-022-00049-y
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This research was supported by JSPS Grants-in-Aid for Scientific Research(B) (No.18H01338 and 21H01215).
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Todo, M., Kurita, H. Comparison of stress–strain response of iPS cell-derived cardiomyocytes sheet and tube structures. Mech Soft Mater 4, 10 (2022). https://doi.org/10.1007/s42558-022-00048-z
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DOI: https://doi.org/10.1007/s42558-022-00048-z