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Ulmus wallichiana Planchon: A vulnerable Himalayan native with immense medicinal value

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Abstract

Ulmus wallichiana Planchon is a tree of immense medicinal importance whose habitat extends from central Nuristan in Afghanistan, traversing Gilgit-Baltistan of Pakistan, and reaching Northern India and western Nepal. It has been utilized as an astringent, demulcent, emollient, expectorant, and diuretic. The tree’s bark has specifically been employed in folk medicine for healing bone fractures in both animals and humans. This plant exhibits significant therapeutic and economic potential due to the presence of various C-glycosylated flavonoids, which have thoroughly been examined for their characteristics related to osteoporosis as well as osteoclastogenesis. Furthermore, extensive research has uncovered a diverse array of pharmacological properties attributed to this particular plant species, including anti-hypertensive, anti-oxidant, anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, anti-hyperglycemic, cardioprotective, and neuroprotective effects. Unfortunately, due to excessive exploitation in its natural habitats, this valuable species has experienced a reduction in both i.e., its species diversity and overall tree density, resulting in its classification as a vulnerable species.

Addressing the need for sustainable approaches like micropropagation is crucial for conserving this elite plant species for commercial production of its bioactive compounds to manage diverse ailments.

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References

  • Abdul R, Anil S (2012) Exploration of economically important fodder plants of district Rajouri-Jammu and Kashmir State. Int J Life Sci Pharma Res 2:142

    Google Scholar 

  • Agarwal M, Kamal R (2007) Studies on flavonoid production using in vitro cultures of Momordica charantia L. Indian J Biotechnol 6:277–279

    CAS  Google Scholar 

  • Agati G, Azzarello E, Pollastri S, Tattini M (2012) Flavonoids as antioxidants in plants: location and functional significance. Plant Sci 196:67–76

    Article  CAS  PubMed  Google Scholar 

  • Aibinu I, Aednipekun E, Odugbemi T (2004) ’Emergence of quinolone resistance amongst escherichia coli strains isolated from clinical infections in some lagos state hospitals Nigeria. Nigerian J Health Biomed Sci 3:73–78

    Google Scholar 

  • Ajaib M (2014). Ethnobotanical studies of useful trees of District Kotli, Azad Jammu and Kashmir.

  • Almeida M, Han Li, Ambrogini E, Weinstein RS, Manolagas SC (2011) Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem 286:44326–44335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amin S, Lavalley MP, Simms RW, Felson DT (2002) The comparative efficacy of drug therapies used for the management of corticosteroid-induced osteoporosis: a meta-regression. J Bone Miner Res 17:1512–1526

    Article  CAS  PubMed  Google Scholar 

  • Anita T, Dinesh K (2018) Propagation of Ulmus wallichiana from divergent sources of north India. Indian Forester 144:1162–1165

    Google Scholar 

  • Apetz N, Munch G, Govindaraghavan S, Gyengesi E (2014) Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer’s disease–a translational perspective. CNS Neurol Disorders Drug Targets 13:1175–1191

    Article  CAS  Google Scholar 

  • Arya KR, Sharma D, Kumar B (2011) Validation and quality determination of an ethnobotanical lead for osteogenic activity isolated from Ulmus wallichiana Planch.: A traditional plant for healing fractured bones, J Sci Indus Res, 360–64.

  • Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA (2004) The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 79:326–333

    Article  CAS  PubMed  Google Scholar 

  • Bensouici C, Kabouche A, Karioti A, Öztürk M, Duru ME, Bilia AR, Kabouche Z (2016) Compounds from Sedum caeruleum with antioxidant, anticholinesterase, and antibacterial activities. Pharm Biol 54:174–179

    Article  CAS  PubMed  Google Scholar 

  • Binic I, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D (2013) Skin ageing: natural weapons and strategies. Evid Based Complem Altern Med 2013:827248–827348

    Article  Google Scholar 

  • Biroščíková M, Spišáková K, Lipták Š, Pichler V, Ďurkovič J (2004) Micropropagation of mature wych elm (Ulmus glabra Huds.). Plant Cell Rep 22:640–644

    Article  PubMed  Google Scholar 

  • Bishayee K, Ghosh S, Mukherjee A, Sadhukhan R, Mondal J, Khuda-Bukhsh AR (2013) Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. Cell Prolif 46:153–163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bora KS, Kumar A, Bisht G (2018) Evaluation of antimicrobial potential of successive extracts of Ulmus wallichiana Planch. J Ayurveda Integr Med 9:190–194

    Article  PubMed  Google Scholar 

  • Bose B, Choudhury H, Tandon P, Kumaria S (2017) Studies on secondary metabolite profiling, anti-inflammatory potential, in vitro photoprotective and skin-aging related enzyme inhibitory activities of Malaxis acuminata, a threatened orchid of nutraceutical importance. J Photochem Photobiol B 173:686–695

    Article  CAS  PubMed  Google Scholar 

  • Brito F, Ana MR, Abrantes AM, Pires AS, Teixo RJ, Tralhao JG, Botelho MF (2015) Quercetin in cancer treatment, alone or in combination with conventional therapeutics? Curr Med Chem 22:3025–3039

    Article  CAS  PubMed  Google Scholar 

  • Brunetti C, Di Ferdinando M, Fini A, Pollastri S, Tattini M (2013) Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans. Int J Mol Sci 14:3540–3555

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Canalis E, Mazziotti G, Giustina A, Bilezikian JP (2007) Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int 18:1319–1328

    Article  CAS  PubMed  Google Scholar 

  • Canderelli R, Leccesse LA, Miller NL, Davidson JU (2007) Benefits of hormone replacement therapy in postmenopausal women. J Am Acad Nurse Pract 19:635–641

    Article  PubMed  Google Scholar 

  • Carpinteri R, Porcelli T, Mejia C, Patelli I, Bilezikian JP, Canalis E, Angeli A, Giustina A, Mazziotti G (2010) Glucocorticoid-induced osteoporosis and parathyroid hormone. J Endocrinol Invest 33:16–21

    CAS  PubMed  PubMed Central  Google Scholar 

  • Carte BK, Carr S, DeBrosse C, Hemling ME, MacKenzie L, Offen P, Berry DE (1991) Aciculatin, a novel flavone-C-glycoside with DNA binding activity from Chrysopogon aciculatis. Tetrahedron 47:1815–1822

    Article  CAS  Google Scholar 

  • Chalupa V (1994) Micropropagation and preservation of elms (Ulmus carpinifolia Gled. and Ulmus montana Stok.) by biotechnological methods. Forestry 40:507–512

    Google Scholar 

  • Chen S, Yuan J, Yao S, Jin Y, Chen G, Tian W, Xi J, Zhelong Xu, Weng D, Chen J (2015) Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. Autophagy 11:2346–2357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coxam V (2005) New advances in osteoporosis nutritional prevention. Med Sci 21:297–301

    Google Scholar 

  • Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM (2006) Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 4:1035–1038

    Article  CAS  PubMed  Google Scholar 

  • Davinelli S, Bertoglio JC, Polimeni A, Scapagnini G (2018) Cytoprotective polyphenols against chronological skin aging and cutaneous photodamage. Curr Pharm Des 24:99–105

    Article  CAS  PubMed  Google Scholar 

  • Deng W, Jiang D, Fang Yi, Zhou H, Cheng Z, Lin Y, Zhang R, Zhang J, Peng Pu, Liu Y (2013) Hesperetin protects against cardiac remodelling induced by pressure overload in mice. J Mol Histol 5:575–585

    Article  Google Scholar 

  • Dilshara MG, Lee KT, Kim HJ, Lee HJ, Choi YH, Lee CM, Kim LK, Kim GY (2014) Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells. Cell Immunol 290:21–29

    Article  CAS  PubMed  Google Scholar 

  • Dimayuga RE, Garcia SK (1991) Antimicrobial screening of medicinal plants from Baja California Sur Mexico. J Ethnopharmacol 31:181–192

    Article  Google Scholar 

  • Dong J, Zhang X, Zhang L, Bian H-X, Na Xu, Bao B, Liu J (2014) Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1. J Lipid Res 55:363–374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dunnick JK, Hailey JR (1992) Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol 19:423–431

    Article  CAS  PubMed  Google Scholar 

  • Edlind MP, Hsieh AC (2014) PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance. Asian J Androl 16:378–386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fang N, Sanggong Yu, Mabry TJ (1986) Flavonoids from Ageratina calophylla. Phytochemistry 25:2684–2686

    Article  CAS  Google Scholar 

  • Fenning TM, Gartland KMA, Brasier CM (1993) Micropropagation and regeneration of English elm, Ulmus procera Salisbury. J Exp Bot 44:1211–1217

    Article  Google Scholar 

  • Fernandes V, Sharma D, Kalia K, Tiwari V (2018) Neuroprotective effects of silibinin: An in silico and in vitro study. Int J Neurosci 128:935–945

    Article  CAS  PubMed  Google Scholar 

  • Fernández-Moriano C, Gómez-Serranillos MP, Crespo A (2016) Antioxidant potential of lichen species and their secondary metabolites. A systematic review. Pharm Biol 54:1–17

    Article  PubMed  Google Scholar 

  • Ferry DR, Smith A, Malkhandi J, Fyfe DW, Anderson D, Baker J, Kerr DJ (1996) Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2:659–668

    CAS  PubMed  Google Scholar 

  • Gartland JS, McHugh AT, Brasier CM, Irvine RJ, Fenning TM, Gartland KMA (2000) Regeneration of phenotypically normal English elm (Ulmus procera) plantlets following transformation with an Agrobacterium tumefaciens binary vector. Tree Physiol 20:901–907

    Article  CAS  PubMed  Google Scholar 

  • Gupta P, Singh A, Tiwari S, Mishra A, Maurya R, Singh S (2019) Ulmosides A: Flavonoid 6-C-glycosides from Ulmus wallichiana attenuates lipopolysacchride induced oxidative stress, apoptosis and neuronal death. Neurotoxicology 73:100–111

    Article  CAS  PubMed  Google Scholar 

  • Gurib-Fakim A (2006) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 27:1–93

    Article  CAS  PubMed  Google Scholar 

  • Hamidullah RK, Saini KS, Kumar A, Sudhir Kumar E, Ramakrishna RM, Konwar R, Chattopadhyay N (2015) Quercetin-6-C-β-d-glucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor. Biochimie 119:68–79

    Article  CAS  PubMed  Google Scholar 

  • Hammoud RA, Vaccari CS, Nagamia SH, Khan BV (2007) Regulation of the renin–angiotensin system in coronary atherosclerosis: a review of the literature. Vas Health Risk Management 3:937–945

    CAS  Google Scholar 

  • Han J-J, Hao J, Kim C-H, Hong J-S, Ahn H-Y, Lee Y-S (2009) Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. J Vet Med Sci 71:737–743

    Article  CAS  PubMed  Google Scholar 

  • Hao J, Kim C-H, Ha T-S, Ahn H-Y (2007) Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats. J Vet Sci 8:121–129

    Article  PubMed  PubMed Central  Google Scholar 

  • Haq F (2012) The critically endangered flora and fauna of district Battagram Pakistan. Adv Life Sci 2:118–123

    Article  Google Scholar 

  • Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179–2205

    Article  CAS  PubMed  Google Scholar 

  • He T, Chen L, Chen Y, Han Yi, Yang W-Q, Jin M-W (2011) In vivo and in vitro protective effects of pentamethylquercetin on cardiac hypertrophy. Cardiovasc Drugs Ther 26:109–120

    Article  Google Scholar 

  • Heybroek HM (2000) 15 Notes on Elm Breeding, The Elms: Breeding, Conservation, and Disease Management, 249 pp

  • Hirobe C, Qiao Z-S, Takeya K, Itokawa H (1997) Cytotoxic flavonoids from Vitex agnus-castus. Phytochemistry 46:521–524

    Article  CAS  PubMed  Google Scholar 

  • Hollman PCH, Bijsman MNCP, Van Gameren Y, Cnossen EPJ, De Vries JHM, Katan MB (1999) The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radical Res 31:569–573

    Article  CAS  Google Scholar 

  • Horcajada-Molteni M-N, Crespy V, Coxam V, Davicco M-J, Rémésy C, Barlet J-P (2000) Rutin inhibits ovariectomy-induced osteopenia in rats. J Bone Miner Res 15:2251–2258

    Article  CAS  PubMed  Google Scholar 

  • Houghton PJ, Howes M-J (2005) Natural products and derivatives affecting neurotransmission relevant to Alzheimer’s and Parkinson’s disease. Neurosignals 14:6–22

    Article  CAS  PubMed  Google Scholar 

  • Huffman MD, Prabhakaran D (2010) Heart failure: Epidemiollogy and prevention in India. Natl Med J India 23:283–288

    PubMed  PubMed Central  Google Scholar 

  • Hunter JE (2001) Studies on effects of dietary fatty acids as related to their position on triglycerides. Lipids 36:655–668

    Article  CAS  PubMed  Google Scholar 

  • Jain, Sudhanshu Kumar. 1991. Dictionary of Indian folk medicine and ethnobotany (Deep publications).

  • Jalili T, Carlstrom J, Kim S, Freeman D, Jin H, Tzu-Ching Wu, Litwin SE, David J (2006) Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. J Cardiovasc Pharmacol 47:531–541

    Article  CAS  PubMed  Google Scholar 

  • Kalustian P (1985) Pharmaceutical and cosmetic uses of palm and lauric products. J Am Oil Chem Soc 62:431–433

    Article  CAS  Google Scholar 

  • Karnosky DF, Mickler RA, Lange DD (1982) Hormonal-control of shoot and root induction in hypocotyl callus-cultures of American Elm. J Tissue Culture Assoc 25:275–375

    Google Scholar 

  • Katske F, Shoskes DA, Sender M, Poliakin R, Gagliano K, Rajfer J (2001) Treatment of interstitial cystitis with a quercetin supplement. Tech Urol 7:44–46

    CAS  PubMed  Google Scholar 

  • Khan MP, Mishra JS, Sharan K, Yadav M, Singh AK, Srivastava A, Kumar S, Bhaduaria S, Maurya R, Sanyal S (2013) A novel flavonoid C-glucoside from Ulmus wallichiana preserves bone mineral density, microarchitecture and biomechanical properties in the presence of glucocorticoid by promoting osteoblast survival: a comparative study with human parathyroid hormone. Phytomedicine 20:1256–1266

    Article  CAS  PubMed  Google Scholar 

  • Khare CP (2008) Indian medicinal plants: an illustrated dictionary. Springer Science & Business Media, Berlin

    Google Scholar 

  • Khosla S, Westendorf JJ, Oursler MJ (2008) Building bone to reverse osteoporosis and repair fractures. J Clin Investig 118:421–428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim B-W, Koppula S, Hong S-S, Jeon S-B, Kwon J-H, Hwang B-Y, Park E-J, Choi D-K (2013) Regulation of microglia activity by glaucocalyxin-A: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways. PLoS ONE 8:e55792

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim B-W, Koppula S, Park S-Y, Kim Y-S, Park P-J, Lim J-H, Kim I-S, Choi D-K (2015a) Attenuation of neuroinflammatory responses and behavioral deficits by Ligusticum officinale (Makino) Kitag in stimulated microglia and MPTP-induced mouse model of Parkinson׳ s disease. J Ethnopharmacol 164:388–397

    Article  PubMed  Google Scholar 

  • Kim MJ, Park M, Kim DW, Shin MJ, Son O, Jo HS, Yeo HJ, Cho SB, Park JH, Lee CH (2015b) Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson’s disease model. Biomaterials 64:45–56

    Article  CAS  PubMed  Google Scholar 

  • Kumari T, Sharma C, Bajpai V, Kumar B, Srivastava M, Arya KR (2015) Qualitative determination of bioactive metabolites through Q-TOF LC/MS in different parts and undifferentiated cultures of Ulmus wallichiana Planchon. Plant Growth Regul 75:331–340

    Article  CAS  Google Scholar 

  • Kuwabara T, Imajoh-ohmi S (2004) LPS-induced apoptosis is dependent upon mitochondrial dysfunction. Apoptosis 9:467

    Article  CAS  PubMed  Google Scholar 

  • Lee SH, Lee JH, Eun Young Oh, Kim G-Y, Choi BT, Kim C, Choi YH (2013) Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-κB nuclear translocation and the activation of the PI3K/Akt signaling pathway. Int J Mol Med 32:876–882

    Article  PubMed  Google Scholar 

  • Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP (1990) Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322:1561–1566

    Article  CAS  PubMed  Google Scholar 

  • Li F, Wang S-C, Wang X, Ren Q-Y, Wang W, Shang G-W, Zhang L, Zhang S-H (2008) Novel exploration of cathartic pharmacology induced by rhubarb. China J Chin Mater Medica 33:481–484

    Google Scholar 

  • Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R (2009) The sequence alignment/map format and SAMtools. Bioinformatics 25:2078–2079

    Article  PubMed  PubMed Central  Google Scholar 

  • Li H, Qian W, Weng X, Zhihong Wu, Li H, Zhuang Q, Feng B, Bian Y (2012) Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells. PLoS ONE 7:e37030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lorente FT, Ferreres F, Barberan FAT (1982) 6-C-glucosylnaringenin from flowers of Acacia retinoide. Phytochemistry 21:1461–1462

    Article  CAS  Google Scholar 

  • Malá J (2000) Micropropagation of mature elm trees in vitro. J for Sci 46:260–264

    Google Scholar 

  • Marais C, Janse van Rensburg W, Ferreira D, Steenkamp JA (2000) S)-and (R)-Eriodictyol-6-C-ß-D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis. Phytochemistry 55:43–49

    Article  CAS  PubMed  Google Scholar 

  • Masoodi TH, Islam MA, Wani MA, Mir SA, Gangoo SA (2013) Allelopathic effect of Populus deltoides and Ulmus wallichiana on biochemical constituents of maize, bean and sunflower. Karnataka J Agric Sci 26:265–267

    Google Scholar 

  • Matsubara Y, Sawabe A (1994) Biologically active compounds in citrus fruit peels. J Synth Org Chem Jpn 52:318–327

    Article  CAS  Google Scholar 

  • Maurya R, Rawat P, Sharan K, Siddiqui JA, Mishra G, Manickavasagam L, Arya KR, Chattopadhyay N (2009) Novel flavonol compounds, A bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention for treatment of osteo-health related disorders (Patent number with date: No. WO/2009/110003 dated 11. 09. 2009).

  • Maurya R, Rawat P, Sharan K, Siddiqui JA, Swarnkar G, Mishra G, Manickavasagam L, Jain GK, Arya KR, Chattopadhyay N (2014) Flavonol compounds, a bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention for treatment of osteo-health related disorders. In.: Google Patents.

  • Mazziotti G, Angeli A, Bilezikian JP, Canalis E, Giustina A (2006) Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab 17:144–149

    Article  CAS  PubMed  Google Scholar 

  • McMurray JJ, Petrie MC, Murdoch DR, Davie AP (1998) Clinical epidemiology of heart failure: public and private health burden. Eur Heart J 19:P9-16

    PubMed  Google Scholar 

  • Mehmood A, Shabir S, Hussain S, Ahmad KS, Hamid A (2019) Antibacterial and antioxidant activity of biosynthesized silver nanoparticles from Ulmus wallichiana Planch leaf extract. Farmacia 67:662–669. https://doi.org/10.31925/farmacia.2019.4.16

    Article  CAS  Google Scholar 

  • Mehta JL, Ding Z, Liu S, Wang XW, Khaidakov M (2014) Hypertension, TLR4 activation in brain and cardiac hypertrophy. Oxford University Press, Oxford

    Book  Google Scholar 

  • Melville R, Heybroek HM (1971) The elms of the Himalaya. Kew Bull 26:5–28

    Article  Google Scholar 

  • Misawa M (1985) Production of useful plant metabolites: 59–88, Flechter A.,(Ed.).

  • Mittal BV, Singh AK (2010) Hypertension in the developing world: challenges and opportunities. Am J Kidney Dis 55:590–598

    Article  PubMed  Google Scholar 

  • Monteuuis O. (2016) Micropropagation and production of forest trees.

  • Moreillon P, Que Y, Glauser MP (2005) Staphylococcus aureus, Principles and Practice of Infectious Diseases, 6a edn. Churchill-Livingston, Philadelphia, pp 2321–2351

    Google Scholar 

  • Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G (2010) Mitochondrial dysfunction is a trigger of Alzheimer’s disease pathophysiology. Biochimica Et Biophysica Acta (BBA) 1802:2–10

    Article  CAS  PubMed  Google Scholar 

  • Mughal AH, Mugloo JA (2016) Elm (Ulmus wallichiana): A vulnerable lesser known multipurpose tree species of Kashmir valley. SKUAST J Res 18:73–79

    Google Scholar 

  • Nagai T, Miyaichi Y, Tomimori T, Suzuki Y, Yamada H (1990) Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. Chem Pharm Bull 38:1329–1332

    Article  CAS  Google Scholar 

  • Nassar AH, Abd HM, Essamad JT, Awwad NG (2005) Gynecologists attitudes towards hormone therapy in the post “Women’s Health Initiative” study era. Maturitas 52:18–25

    Article  PubMed  Google Scholar 

  • Nazir I, Dutt V, Anup Raj GM, Bhat BA (2020) Effect of IBA concentrations on rooting and growth of Ulmus wallichiana Planchon stem cuttings under temperate conditions of Kashmir. J Pharmacogn Phytochem 9:2446–2449

    Article  CAS  Google Scholar 

  • Nazir I, Dutt V, Anup Raj GM, Bhat BA (2021) Vegetative propagation of Ulmus villosa Brandis and Ulmus wallichiana Planchon: optimizing plant growth regulators and growing media on root formation in hardwood stem cuttings. Curr Sci 121:691

    Article  CAS  Google Scholar 

  • Neha S, Karuna T, Sanjeev K, Arya KR (2018) Vegetative propagation and Liquid Chromatography Mass Spectrometry (LCMS) analysis of Indian traditional and endangered plant Ulmus wallichiana using air layering technology. Indian Forester 144:723–729

    Google Scholar 

  • Nengroo ZR, Rauf A (2019) Fatty acid composition and antioxidant activities of five medicinal plants from Kashmir. Ind Crops Prod 140:111596

    Article  CAS  Google Scholar 

  • Ning Q, Liu Z, Wang X, Zhang R, Zhang J, Yang M, Sun H, Han F, Zhao W, Zhang X (2017) Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice. Neurol Res 39:357–366

    Article  CAS  PubMed  Google Scholar 

  • Oh WK, Lee CH, Lee MS, Bae EY, Sohn CB, Hyuncheol Oh, Kim BY, Ahn JS (2005) Antidiabetic effects of extracts from Psidium guajava. J Ethnopharmacol 96:411–415

    Article  PubMed  Google Scholar 

  • Oh K-S, Ryu SY, Byung Koo Oh, Seo HW, Kim YS, Lee BH (2008) Antihypertensive, vasorelaxant, and antioxidant effect of root bark of Ulmus macrocarpa. Biol Pharm Bull 31:2090–2096

    Article  CAS  PubMed  Google Scholar 

  • Okamoto T (2005) Safety of quercetin for clinical application. Int J Mol Med 16:275–278

    CAS  PubMed  Google Scholar 

  • Oparil S, Amin Zaman M, Calhoun DA (2003) Pathogenesis of hypertension. Ann Intern Med 139:761–776

    Article  CAS  PubMed  Google Scholar 

  • Ortiz-Andrade RR, Rodríguez-López V, Garduño-Ramírez ML, Castillo-España P, Estrada-Soto S (2005) Anti-diabetic effect on alloxanized and normoglycemic rats and some pharmacological evaluations of Tournefortia hartwegiana. J Ethnopharmacol 101:37–42

    Article  CAS  PubMed  Google Scholar 

  • Pehu T, Kiviharju E, Rusanen M, Kantanen J, Heinimaa P (2020) Finland's National Genetic Resources Programme for Agriculture, Forestry and Fishery: Summary of the Finland's National Genetic Resources Programme for Agriculture, Forestry and Fishery

  • Plummer S, Van den Heuvel C, Thornton E, Corrigan F, Cappai R (2016) The neuroprotective properties of the amyloid precursor protein following traumatic brain injury. Aging Dis 7:163

    Article  PubMed  PubMed Central  Google Scholar 

  • Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman Jr JW (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68:1375S-S1379

    Article  CAS  PubMed  Google Scholar 

  • Ramesh, P, Ramachandran Nair AG, Subramanian SS (1986) Flavone glycosides of Vitex trifolia, Fitoterapia.

  • Rawat P, Kumar M, Sharan K, Chattopadhyay N, Maurya R (2009) Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase. Bioorg Med Chem Lett 19:4684–4687

    Article  CAS  PubMed  Google Scholar 

  • Rawat P, Kumar M, Rahuja N, Srivastava DSL, Srivastava AK, Maurya R (2011) Synthesis and antihyperglycemic activity of phenolic C-glycosides. Bioorg Med Chem Lett 21:228–233

    Article  CAS  PubMed  Google Scholar 

  • Reddy GAK, Priyanka B, Saranya ChS, Kumar CKA (2012) Wound healing potential of Indian medicinal plants. Int J Pharm Rev Res 2:75–87

    Google Scholar 

  • Rees DA, Alcolado JC (2005) Animal models of diabetes mellitus. Diabet Med 22:359–370

    Article  CAS  PubMed  Google Scholar 

  • Rietjens IMCM, Boersma MG, van der Woude H, Jeurissen SMF, Schutte ME, Alink GM (2005) Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutation Res 574:124–138

    Article  CAS  PubMed  Google Scholar 

  • Rotella DP (2004) Novel “second-generation” approaches for the control of type 2 diabetes. J Med Chem 47:4111–4112

    Article  CAS  PubMed  Google Scholar 

  • Russo GL (2007) Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74:533–544

    Article  CAS  PubMed  Google Scholar 

  • Sato M, Westmore M, Ma YL, Schmidt A, Zeng QQ, Glass EV, Vahle J, Brommage R, Jerome CP, Turner CH (2004) Teriparatide [PTH (1–34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity. J Bone Miner Res 19:623–629

    Article  CAS  PubMed  Google Scholar 

  • Saydah SH, Fradkin J, Cowie CC (2004) Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291:335–342

    Article  CAS  PubMed  Google Scholar 

  • Schäcke H, Döcke W-D, Asadullah K (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96:23–43

    Article  PubMed  Google Scholar 

  • Scotti L, Scotti MT (2015) Computer aided drug design studies in the discovery of secondary metabolites targeted against age-related neurodegenerative diseases. Curr Top Med Chem 15:2239–2252

    Article  CAS  PubMed  Google Scholar 

  • Sharan K, Siddiqui JA, Swarnkar G, Maurya R, Chattopadhyay N (2009) Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharmacokinetic studies. Curr Med Chem 16:1138–1157

    Article  CAS  PubMed  Google Scholar 

  • Sharan K, Siddiqui JA, Swarnkar G, Tyagi AM, Kumar A, Rawat P, Kumar M, Nagar GK, Arya KR, Manickavasagam L (2010) Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect. Menopause 17:393–402

    Article  PubMed  Google Scholar 

  • Sharma C, Rajendar K, Kumari T, Arya KR (2014) Indian traditional therapies and bio-prospecting: their role in drug development research. Int J Pharm Life Sci 5:730–741

    Google Scholar 

  • Shen Yu, Ward NC, Hodgson JM, Puddey IB, Wang Y, Zhang Di, Maghzal GJ, Stocker R, Croft KD (2013) Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. Free Radical Biol Med 65:908–915

    Article  CAS  Google Scholar 

  • Sheng R, Zhen-lun Gu, Xie M-L, Zhou W-X, Guo C-y (2007) EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats. Acta Pharmacol Sin 28:191–201

    Article  CAS  PubMed  Google Scholar 

  • Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54:960–963

    Article  CAS  PubMed  Google Scholar 

  • Shoskes DA, Sender M, Poliakin R, Gagliano K, Rajfer J (2001) Treatment of interstitial cystitis with a quercetin supplement. Tech Urol 7:44–46

    PubMed  Google Scholar 

  • Singh, SK, and GS Rawat. 1999. 'Floral diversity and vegetation structure in great Himalayan national park, western Himalaya'.

  • Somanath PR, Vijai J, Kichina JV, Byzova T, Kandel ES (2009) The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. Oncogene 28:2365–2369

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stankov-Jovanović VP, Ilić MD, Mitić VD, Mihajilov-Krstev TM, Simonović SR, Nikolić Mandić SD, Tabet JC, Cole RB (2015) Secondary metabolites of Seseli rigidum: Chemical composition plus antioxidant, antimicrobial and cholinesterase inhibition activity. J Pharm Biomed Anal 111:78–90

    Article  PubMed  Google Scholar 

  • Suri S, Liu XH, Rayment S, Hughes DA, Kroon PA, Needs PW, Taylor MA, Tribolo S, Wilson VG (2010) Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 159:566–575

    Article  CAS  PubMed  Google Scholar 

  • Swarnkar G, Sharan K, Siddiqui JA, Chakravarti B, Rawat P, Kumar M, Arya KR, Maurya R, Chattopadhyay N (2011) A novel flavonoid isolated from the steam-bark of Ulmus Wallichiana Planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation. Eur J Pharmacol 658:65–73

    Article  CAS  PubMed  Google Scholar 

  • Syed AA, Lahiri S, Mohan D, Valicherla GR, Gupta AP, Kumar S, Maurya R, Bora HK, Hanif K, Gayen JR (2016) Cardioprotective effect of ulmus wallichiana planchon in β-adrenergic agonist induced cardiac hypertrophy. Front Pharmacol 7:510

    Article  PubMed  PubMed Central  Google Scholar 

  • Synge, Hugh. 1978. The IUCN Plant Red Data Book: comprising red data sheets on 250 selected plants threatened on a world scale (IUCN).

  • Tamura G, Gold C, Ferro-Luzzi A, Ames BN (1980) Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. Proc Natl Acad Sci 77:4961–4965

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tiwari R, Mohan M, Kasture S, Maxia A, Ballero M (2009) Cardioprotective potential of myricetin in isoproterenol-induced myocardial infarction in Wistar rats. Phytotherapy Res 23:1361–1366

    Article  CAS  Google Scholar 

  • Tsujimoto I, Hikoso S, Yamaguchi O, Kashiwase K, Nakai A, Takeda T, Watanabe T, Taniike M, Matsumura Y, Nishida K (2005) The antioxidant edaravone attenuates pressure overload–induced left ventricular hypertrophy. Hypertension 45:921–926

    Article  CAS  PubMed  Google Scholar 

  • Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JPE (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3:115–126

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Venigalla M, Gyengesi E, Münch G (2015) Curcumin and Apigenin–novel and promising therapeutics against chronic neuroinflammation in Alzheimer’s disease. Neural Regen Res 10:1181–1185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verma DK, Gupta S, Biswas J, Joshi N, Singh A, Gupta P, Shubhangini Tiwari K, Raju S, Chaturvedi S, Wahajuddin M (2018) New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. Biochimica Et Biophysica Acta (BBA) 1864:2078–96

    Article  CAS  Google Scholar 

  • Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J (2006) Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 287:109–116

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Wang H, Shao H, Tang X (2016) Recent advances in utilizing transcription factors to improve plant abiotic stress tolerance by transgenic technology. Front Plant Sci 7:67

    PubMed  PubMed Central  Google Scholar 

  • Wattel A, Kamel S, Mentaverri R, Lorget F, Prouillet C, Petit J-P, Fardelonne P, Brazier M (2003) Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochem Pharmacol 65:35–42

    Article  CAS  PubMed  Google Scholar 

  • Weinstein RS, Chen J-R, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Michael Parfitt A, Manolagas SC (2002) Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Investig 109:1041–1048

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yan L, Zhang JD, Wang Bo, Lv YJ, Jiang H, Liu GL, Qiao Y, Ren M, Guo XF (2013) Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-γ expression and suppressing AP-1 activity. PLoS ONE 8:e72548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang F, Song L, Wang H, Wang J, Zhiqing Xu, Xing N (2015) Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential. Oncol Rep 33:2659–2668

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors are highly grateful to the SKUAST-K for the support and facilities.

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  1. Genome Engineering and Societal Biotechnology Laboratory, Division of Plant Biotechnology, SKUAST-K, Shalimar, Srinagar, Jammu and Kashmir, India

    Mehak Aslam, Arshy Hussain & Amjad M. Husaini

  2. Division of Silviculture and Agroforestry, Faculty of Forestry, Benhama, Ganderbal, Jammu and Kashmir, India

    Mehak Aslam, Arshy Hussain & Vaishnu Dutt

  3. Department of Plant Production and Genetics, Faculty of Agriculture, University of Birjand, Birjand, Iran

    Hamid-Reza Fallahi

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MA wrote the paper together with critical inputs from AH, VD and AMH. AMH and HRF conceptualized, analysed and edited the manuscript. All authors contributed to the article and approved the submitted version.

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Aslam, M., Hussain, A., Dutt, V. et al. Ulmus wallichiana Planchon: A vulnerable Himalayan native with immense medicinal value. Vegetos (2024). https://doi.org/10.1007/s42535-024-00859-7

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