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Clinical Improvement of Progressive Multifocal Leukoencephalopathy Following Pembrolizumab Infusion: a Case Report

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Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic brain infection caused by the John Cunningham (JC) virus, the cardinal feature of which is typically multifocal demyelination. In April 2019, pembrolizumab was investigated as a treatment for PML. We describe a case of a patient with progressive multifocal leukoencephalopathy in an Irish tertiary hospital, who experienced clinical improvement following one course of pembrolizumab.

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Authors and Affiliations

  1. Department of Neurology, St Vincent’s University Hospital, Dublin, Ireland

    Z. Togher, S. Fullam, A. Gunko & C. McGuigan

Authors
  1. Z. Togher
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  2. S. Fullam
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  3. A. Gunko
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  4. C. McGuigan
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Contributions

All authors were involved in the care of the patient. ZT wrote the initial manuscript with input from SF and AG. CMcG edited and approved the final manuscript.

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Correspondence to Z. Togher.

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The authors declare that they have no conflict of interest.

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Written consent has been obtained from the patient and is available on request.

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This article is part of the Topical Collection on Medicine

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Togher, Z., Fullam, S., Gunko, A. et al. Clinical Improvement of Progressive Multifocal Leukoencephalopathy Following Pembrolizumab Infusion: a Case Report. SN Compr. Clin. Med. 3, 320–322 (2021). https://doi.org/10.1007/s42399-020-00678-2

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  • DOI: https://doi.org/10.1007/s42399-020-00678-2

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