Abstract
Objective: Examine factors contributing to the relationship between sleep-wake dysfunction and subacute post-concussion syndrome. Setting: Data collection online via Qualtrics survey. Participants: Forty seven adults reporting recent TBI recruited via Facebook and Reddit. Design: Moderation analysis via hierarchical multiple regression procedure. Main Measures: Neurobehavioral Symptom Inventory, Epworth Sleepiness Scale, Patient Health Questionnaire, General Anxiety Disorder Scale, and a General Health Questionnaire. Results: A relationship between sleep-wake dysfunction and symptoms of subacute post-concussion syndrome was observed. While premorbid mental health did not interact with this relationship, recent endorsement of depression and anxiety symptoms moderated the association. Exploratory analysis also suggested duration of posttraumatic amnesia inflated this relationship. Conclusion: These findings suggest that patients reporting post-concussive sleep dysfunction may benefit from mental health support. They also provide insight in to which early factors may be associated with the development of a sleep-related protracted recovery profile following a traumatic brain injury.
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All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained for all individual participants in the study and participants’ rights were protected. This study was conducted with grant funding through Southern Illinois University Edwardsville (SIUE). These data have not been published previously and are not under consideration for publication elsewhere. The authors assert no conflicts of interest. This study was approved and granted exempt status on Tuesday, February 12th 2019 by SIUE Social Behavioral Institutional Review Board. All authors listed were significantly involved in this study, and consent to having our names on the manuscript should it be accepted.
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Waller, C.S., Pawlow, L., Pettibone, J.C. et al. Amplifying Factors in the Proposed Relationship between Sleep-Wake Dysfunction and Post-Concussion Syndrome Pathogenesis. SN Compr. Clin. Med. 2, 526–530 (2020). https://doi.org/10.1007/s42399-020-00284-2
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DOI: https://doi.org/10.1007/s42399-020-00284-2