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A capacitive polypyrrole-wrapped carbon cloth/bacterial cellulose antibacterial dressing with electrical stimulation for infected wound healing

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Abstract

The formulation of an antibiotic-free antibacterial approach is imperative in circumventing escalating bacterial drug resistance. Electrical stimulation presents a viable therapeutic modality for such an approach. Nonetheless, obstacles persist in achieving efficacious sterilization with biosafe low-voltage electrical fields (EFs) and enduring antibacterial capabilities. In this study, we have devised a novel capacitive antibacterial dressing comprising polypyrrole-wrapped carbon cloth (PPy-CC) electrodes and a bacterial cellulose (BC) hydrogel separator. Subjected to 1 V electrical stimulation for 10 min, the dressing attains high bactericidal efficiency (up to 99.97%) and enhanced activity against multidrug-resistant (MDR) bacteria (up to 99.99%). Its considerable electric capacity and rechargeability allow for repeated charging to achieve sustained sterilization. In vivo results demonstrate significant inhibition of wound infection and facilitated wound recovery in infected full-thickness defects in mouse models. This represents an antibiotic-free, physically-stimulated treatment modality for infected wounds with considerable potential for clinical application.

TOC

A capacitive antibacterial dressing consists of polypyrrole-wrapped carbon cloth as electrode layer and bacterial cellulose hydrogel as separator with efficiently accelerated infected-wound healing. The resultant hydrogel dressing exhibits excellent high capacitance characteristics, good biocompatibility, efficient and sustained antibacterial ability after low voltage charging. It is an antibiotic-free, physical stimulation-based strategy for infected wounds.

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All data and materials supporting the finding of this study are available within the paper and its supplementary information.

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Acknowledgements

The author also was grateful for the Analytical and Testing Centre of Huazhong University of Science and Technology (HUST) and the test platform of Life Sciences College at HUST for characterization of samples.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No.51973076).

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Authors and Affiliations

  1. Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China

    Hao Wang, Ruizhu Zheng, Pengyu He, Zhijun Shi & Guang Yang

  2. Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430074, China

    Xiaoming Li

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  1. Hao Wang
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  2. Ruizhu Zheng
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  4. Xiaoming Li
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Contributions

Hao Wang, Zhijun Shi, Guang Yang conceived this research and designed experiments. Hao Wang, Ruizhu Zheng, Pengyu He and Xiaoming Li performed experiments, analysis, and interpretation of the data. All authors participated in the interpretation of the data. Hao Wang and Zhijun Shi wrote the paper and participated in the revision of it. All authors read, revised, and approved the final manuscript.

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Correspondence to Zhijun Shi or Guang Yang.

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Wang, H., Zheng, R., He, P. et al. A capacitive polypyrrole-wrapped carbon cloth/bacterial cellulose antibacterial dressing with electrical stimulation for infected wound healing. Adv Compos Hybrid Mater 7, 10 (2024). https://doi.org/10.1007/s42114-023-00814-1

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