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“You are my sunshine, my only sunshine”: maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes

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Abstract

Vitamin D (VD) plays a crucial role in regulating calcium homeostasis, while the wealth of its pleiotropic actions is gaining increasing research interest. Sufficient VD concentrations are of clinical relevance, particularly in the context of physiological alterations, such as those occurring during pregnancy when maternal VD is the sole source for the developing fetus. As a result, inadequate VD concentrations in pregnancy have been associated with perinatal complications and adverse neonatal outcomes, including preeclampsia, gestational diabetes mellitus, increased rates of cesarean section, low birth weight, small-for-gestational-age infants, poor immune and skeletal growth, allergies, and respiratory infections. Over the past few decades, several observational studies have underlined the important role of maternal VD in the neural, musculoskeletal, and psychomotor growth and bone health of the offspring. However, the complexity of the factors involved in regulating and assessing VD homeostasis, including race, sun exposure, dietary habits, and laboratory measurement techniques, makes the interpretation of relevant research findings challenging. The aim of this narrative review is to summarize the evidence on the importance of VD in maintaining optimal health during pregnancy, infancy, childhood, and adolescence.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece

    Dimitra Vasdeki, Theocharis Koufakis & Kalliopi Kotsa

  2. Division of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, UK

    Georgios Tsamos

  3. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Dimitrios G. Goulis

  4. Laboratory of Physiology, Faculty of Medicine, Democritus University of Thrace, Alexandroupoli, Greece

    Byron Asimakopoulos

  5. Sports Medicine Laboratory, School of Physical Education & Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Vassiliki Michou

  6. Department of Internal Medicine, General Hospital of Veroia, Veroia, Greece

    Vasileios Patriarcheas

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  1. Dimitra Vasdeki
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DV, GT, and TK reviewed the literature and drafted the first version of the manuscript. DG, VA, VM, VP, and KK reviewed the literature and edited the manuscript. All authors have read and agreed to the published version of the manuscript.

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Vasdeki, D., Tsamos, G., Koufakis, T. et al. “You are my sunshine, my only sunshine”: maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes. Hormones 22, 547–562 (2023). https://doi.org/10.1007/s42000-023-00486-y

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