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Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex

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Abstract

Naproxen–β-cyclodextrin inclusion complex was prepared by the freeze-drying method and analyzed by IR, UV spectroscopy, X-ray diffractometry and differential scanning calorimetry. Phase solubility, dissolution and inclusion rate of the complex were determined. The phase solubility diagram was of the A L type, which revealed that the molar ratio of naproxen to β-cyclodextrin was 1:1. The solubility of naproxen significantly increased with increasing β-cyclodextrin concentration. The apparent stability constant, K c, was calculated from the slope and intercept of the A L solubility diagram as 2376/M. The total released amount and released time of naproxen from the inclusion complex were better than that of the intact naproxen.

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Acknowledgements

This work was financially supported by the Guangdong Province Science and Technology Program Foundation (No. 2013B040200029), 2016 National Drug Evaluation Special Foundation of China and the National Natural Science Foundation of China (21375027, 21335002, and 21427806).

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Authors and Affiliations

  1. Guangdong Institute for Drug Control, Guangzhou, 510180, People’s Republic of China

    Guiying Jin

  2. Department of Chemistry, Fudan University, Shanghai, 200433, People’s Republic of China

    Hui Chen

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  1. Guiying Jin
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  2. Hui Chen
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Correspondence to Guiying Jin or Hui Chen.

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Jin, G., Chen, H. Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex. J. Anal. Test. 1, 19 (2017). https://doi.org/10.1007/s41664-017-0021-9

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