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A review for the impacts of circadian disturbance on urological cancers

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Abstract

Circadian rhythm is an internal timing system and harmonizes a variety of cellular, behavioral, and physiological processes to daily environment. Circadian disturbance caused by altered life style or disrupted sleep patterns inevitably contributes to various disorders. As the rapidly increased cancer occurrences and subsequent tremendous financial burdens, more researches focus on reducing the morbidity rather than treating it. Recently, many epidemiologic studies demonstrated that circadian disturbance was tightly related to the occurrence and development of cancers. For urinary system, numerous clinical researches observed the incidence and progress of prostate cancer were influenced by nightshift work, sleep duration, chronotypes, light exposure, and meal timing, this was also proved by many genetic and fundamental findings. Although the epidemiological studies regarding the relationship between circadian disturbance and kidney/bladder cancers were relative limited, some basic researches still claimed circadian disruption was closely correlated to these two cancers. The role of circadian chemotherapy on cancers of prostate, kidney, and bladder were also explored, however, it has not been regularly recommended considering the limited evidence and poor standard protocols. Finally, the researches for the impacts of circadian disturbance on cancers of adrenal gland, penis, testis were not found at present. In general, a better understanding the relationship between circadian disturbance and urological cancers might help to provide more scientific work schedules and rational lifestyles which finally saving health resource by reducing urological tumorigenesis, however, the underlying mechanisms are complex which need further exploration.

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Funding

This manuscript was funded by the Science and Technology Foundation Project of Guizhou Provincial Health Commission (gzwkj2024-150), the National Nature Science Foundation of China (No. 82060276 and 82360295), the Science and Technology Department of Guizhou Province (QianKeHeJiChu-ZK[2021]YiBan382), the Sichuan Province Science and Technology Innovation Seedling Project (2021039), and the Doctor Start-up Fund of Affiliated Hospital of Guizhou Medical University (gyfybsky-2023-03).

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Author notes

  1. Tao Li, Yiting Jiang and Yunjin Bai contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, China

    Tao Li, Peng Chen, Chao Luo, Jun Qiao & Jun Shen

  2. Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, China

    Tao Li & Kehua Jiang

  3. Department of Otorhinolaryngology, The Ninth People’s Hospital of Chongqing, Chongqing, China

    Yiting Jiang

  4. Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China

    Yunjin Bai

  5. Translational Medicine Research Center of Guizhou Medical University, Guiyang, China

    Guangshi Du

  6. Gastrointestinal Surgery Center, School of Medicine, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China

    Lei Li

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  1. Tao Li
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Contributions

All authors contributed to the study conception and design. TL, YJ, and YB wrote the first draft of the manuscript; KJ, GD, and PC edited the English language; CL and LL searched and reviewed the referenced papers; JQ and JS reviewed and edited the manuscript. All authors read and approved the manuscript.

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Correspondence to Jun Qiao or Jun Shen.

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Li, T., Jiang, Y., Bai, Y. et al. A review for the impacts of circadian disturbance on urological cancers. Sleep Biol. Rhythms 22, 163–180 (2024). https://doi.org/10.1007/s41105-023-00500-1

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