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Computer Aided Diagnosis Based Hand Thermal Image Analysis: A Potential Tool for the Evaluation of Rheumatoid Arthritis

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Abstract

The aim of the study was to evaluate the potential of the thermogram in diagnosing rheumatoid arthritis and to compare the implementation of k-means algorithm and fuzzy c means algorithm using a computer aided diagnostic tool for classification of rheumatoid arthritis (RA) and normal based on the feature extracted from the segmented thermal image. The skin surface temperature measurement, thermal image segmentation based on k-means and fuzzy c-means algorithm and the feature extraction were used in this study. The average skin surface temperature measured at the second meta carpo-phalangeal (MCP) and MCP3 in RA patients (35.40 ± 0.6 °C and 35.52 ± 0.7 °C, respectively) were significantly higher (p < 0.01) than those measured in normal subjects (33.66 ± 0.2 °C and 33.74 ± 0.2 °C, respectively). The mean difference in temperature between RA patients and healthy controls in the MCP2 and MCP3 region was found to be 1.74 and 1.78 °C respectively. The receiver operating characteristics (ROC) curve depicted a sensitivity of 86.6% and specificity of 79% achieved in the MCP region of the hand thermal image. Thermal image segmentation using the k-means algorithm provided better segmentation results compared to the fuzzy c-means algorithm in diagnosing the disease. Therefore, the computer aided diagnostic based thermography method could be used as a validated quantification method for interpreting and evaluating arthritis.

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Authors and Affiliations

  1. Department of Biomedical Engineering, SRM University, Kattankulathur, Chennai, 603203, Tamilnadu, India

    Snekhalatha Umapathy & Sowmiya Vasu

  2. Centre for Environmental Nuclear Research, SRM University, Kattankulathur, Chennai, 603203, Tamilnadu, India

    Nilkantha Gupta

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  1. Snekhalatha Umapathy
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Correspondence to Snekhalatha Umapathy.

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This manuscript has been read and approved by all the authors. This paper is not under consideration by any other publications and has not been published elsewhere. The authors have no conflicts of interest.

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Umapathy, S., Vasu, S. & Gupta, N. Computer Aided Diagnosis Based Hand Thermal Image Analysis: A Potential Tool for the Evaluation of Rheumatoid Arthritis. J. Med. Biol. Eng. 38, 666–677 (2018). https://doi.org/10.1007/s40846-017-0338-x

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