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Lessons for the clinical nephrologist: a rare pediatric case of interstitial nephritis with karyomegaly

  • Lessons for the Clinical Nephrologist
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References

  1. Fogo AB, Lusco MA, Najafian B, Alpers CE (2016) AJKD atlas of renal pathology: karyomegalic nephropathy. Am J Kidney Dis 68(1):e7. https://doi.org/10.1053/j.ajkd.2016.05.002

    Article  PubMed  Google Scholar 

  2. Naseer MS, Chand R, Coppola S, Abreo A, Sharma M, Singh N (2020) Post-transplant de-novo renal phospholipidosis in a kidney transplant recipient: Fabry disease or something else? Clin Nephrol Case Stud 29(8):46–48

    Article  Google Scholar 

  3. Bhandari S, Kalowski S, Collett P et al (2002) Karyomegalic nephropathy: an uncommon cause of progressive renal failure. Nephrol Dial Transplant 17(11):1914–1920

    Article  CAS  Google Scholar 

  4. Radha S, Tameem A, Rao BS (2014) Karyomegalic interstitial nephritis with focal segmental glomerulosclerosis: a rare association. Indian J Nephrol 24(2):117–119

    Article  CAS  Google Scholar 

  5. McCulloch T, Prayle A, Lunn A, Watson AR (2011) Karyomegalic-like nephropathy, Ewing’s sarcoma and ifosfamide therapy. Pediatr Nephrol 26(7):1163–1166

    Article  Google Scholar 

  6. Matsuura T, Wakino S, Yoshifuji A et al (2014) Improvement in karyomegalic interstitial nephritis three years after ifosfamide and cisplatin therapy by corticosteroid. CEN Case Rep 3(2):226–231

    Article  Google Scholar 

  7. Hempel L, Misselwitz J, Fleck C et al (2003) Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney function. Med Pediatr Oncol 40(6):348–354

    Article  Google Scholar 

  8. Cohen EP, Robbins ME (2003) Radiation nephropathy. Semin Nephrol 23(5):486–499

    Article  Google Scholar 

  9. Airy M, Raghavan R, Truong LD, Eknoyan G (2013) Tubulointerstitial nephritis and cancer chemotherapy: Update on a neglected clinical entity. Nephrol Dial Transplant 28:2502–2509

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Dr. Sushil Gupta (Indiana University School of Medicine, Department of Pediatrics, Division of Nephrology) for his significant contribution to this report and mentorship. We acknowledge Drs. Tarek Ashkar and Kaice LaFavers (Indiana Center for Biological Microscopy, Indiana University School of Medicine) for their work, quantifying renal tubule nuclear size and completing image analysis.

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Correspondence to Carlos C. Becerril Romero.

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The authors have no multiplicity of interests to disclose.

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We obtained consent from the patient's guardian to report a detailed clinical case. Direct identifiers were removed from this report.

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Romero, C.C.B., Kapil, S., Phillips, C.L. et al. Lessons for the clinical nephrologist: a rare pediatric case of interstitial nephritis with karyomegaly. J Nephrol 35, 1721–1724 (2022). https://doi.org/10.1007/s40620-021-01164-1

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  • DOI: https://doi.org/10.1007/s40620-021-01164-1

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