Abstract
This position paper of the study group “Conservative treatment of Chronic Kidney Disease—CKD” of the Italian Society of Nephrology addresses major practical, unresolved, issues related to the conservative treatment of chronic renal disease. Specifically, controversial topics from everyday clinical nephrology practice which cannot find a clear, definitive answer in the current literature or in nephrology guidelines are discussed. The paper reports the point of view of the study group. Concise and practical advice is given on several common issues: renal biopsy in diabetes; dual blockade of the renin–angiotensin–aldosterone system (RAAS); management of iron deficiency; low protein diet; dietary salt intake; bicarbonate supplementation; treatment of obesity; the choice of conservative therapy vs. dialysis. For each topic synthetic statements, guideline-style, are reported.
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Collins AJ, Foley RN, Herzog C, Chavers B, Gilbertson D, Herzog C et al (2013) US renal data system 2012 annual data report. Am J Kidney Dis 61(1 Suppl 1):A7,e1–476
Ritz E, Rychlík I, Locatelli F, Halimi S (1999) End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions. Am J Kidney Dis 34(5):795–808
Mauer M, Caramori ML, Fioretto P, Najafian B (2015) Glomerular structural-functional relationship models of diabetic nephropathy are robust in type 1 diabetic patients. Nephrol Dial Transplant 30(6):918–923
Drummond K, Mauer M, International Diabetic Nephropathy Study Group (2002) The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes. Diabetes 51(5):1580–1587
Pugliese G (2014) Updating the natural history of diabetic nephropathy. Acta Diabetol 51(6):905–915
Sharma SG, Bomback AS, Radhakrishnan J, Herlitz LC, Stokes MB, Markowitz GS, D’Agati VD (2013) The modern spectrum of renal biopsy findings in patients with diabetes. Clin J Am Soc Nephrol 8(10):1718–1724
Zhou J, Chen X, Xie Y, Li J, Yamanaka N, Tong X (2008) A differential diagnostic model of diabetic nephropathy and non-diabetic renal diseases. Nephrol Dial Transplant 23(6):1940–1945
Chong YB, Keng TC, Tan LP, Ng KP, Kong WY, Wong CM et al (2012) Clinical predictors of non-diabetic renal disease and role of renal biopsy in diabetic patients with renal involvement: a single centre review. Ren Fail 34(3):323–328
Serra A, Romero R, Bayés B, Lopez D, Bonet J (2002) Is there a need for changes in renal biopsy criteria in proteinuria in type 2 diabetes? Diabetes Res Clin Pract 58(2):149–153
Mak SK, Gwi E, Chan KW, Wong PN, Lo KY, Lee KF et al (1997) Clinical predictors of non-diabetic renal disease in patients with non-insulin dependent diabetes mellitus. Nephrol Dial Transplant 12(12):2588–2591
Kramer HJ, Nguyen QD, Curhan G, Hsu CY (2003) Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. JAMA 289(24):3273–3277
Dwyer JP, Parving HH, Hunsicker LG, Ravid M, Remuzzi G, Lewis JB (2012) Renal dysfunction in the presence of normoalbuminuria in type 2 diabetes: results from the DEMAND study. Cardiorenal Med 2(1):1–10
Liang S, Zhang XG, Cai GY, Zhu HY, Zhou JH, Wu J et al (2013) Identifying parameters to distinguish non-diabetic renal diseases from diabetic nephropathy in patients with type 2 diabetes mellitus: a meta-analysis. PLoS One 8(5):e64184
Stanton RC (2014) Clinical challenges in diagnosis and management of diabetic kidney disease. Am J Kidney Dis 63(2 Suppl 2):S3–S21
Cernaro V, Trifirò G, Lorenzano G, Lucisano S, Buemi M, Santoro D (2014) New therapeutic strategies under development to halt the progression of renal failure. Expert Opin Investig Drugs 23(5):693–709
Klessens CQ, Woutman TD, Veraar KA, Zandbergen M, Valk EJ, Rotmans JI, Wolterbeek R, Bruijn JA, Bajema IM (2016) An autopsy study suggests that diabetic nephropathy is underdiagnosed. Kidney Int (pii S0085-2538(16)00313-6)
Gesualdo L, Di Paolo S (2015) Renal lesions in patients with type 2 diabetes: a puzzle waiting to be solved. Nephrol Dial Transplant 30(2):155–177
Yusuf S, Teo KK, Pogue J et al (2008) Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 358:1547–1559
Fried LF, Emanuele N, Zhang Jh et al (2013) Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 369:1892–1903
Mann JFE, Schmieder RE, McQueen M et al (2008) Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372:547–555
Palmer SC, Mavridis D, Navarese E et al (2015) Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis. Lancet 385:2047–2056
Heerspink HJ, Kropelin TF, Hoekman J, de Zeeuw D (2015) Drug-induced reduction in albuminuria is associated with subsequent renoprotection: a meta-analysis. J m Soc Nephrol 26:2055–2064
Ruggenenti P, Perticucci E, Cravedi P et al (2008) Role of remission clinics in the longitudinal treatment of CKD. J Am Soc Nephrol 19:1213–1224
Navaneethan SD, Nigwekar SU, Sehgal AR, Strippoli GM (2009) Aldosterone antagonists for preventing the progression of chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol 4:542–551
Bakris GL, Agarwal R, Chen JC et al (2015) Effect of finerenone on albuminuria in patients with diabetic nephropathy. A randomized clinical trial. JAMA 314:884–894
Pitt B, Zannard F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341:709–717
Pitt B, Remme W, Zannad F, Neaton J et al (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309–1321
Slagman MC, Waanders F, Hemmelder MH et al (2011) Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial. BMJ 343:d4366
Heerspink HJL, de Borst MH, Bakker SJL, Navis GJ (2013) Improving the efficacy of RAAs blockade in patients with chronic kidney disease. Nat Rev Nephrol 9:112–121
Hall ME, Wang W, Okhomina V et al (2016) Cigarette smoking and chronic kidney disease in African Americans in the Jackson Heart Study. J Am Heart Assoc. doi:10.1161/JAHA.116.003280
Locatelli F, Bárány P, Covic A et al (2013) Kidney Disease: improving global outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement. Nephrol Dial Transplant 28:1346–1359
Fishbane S, Pollack S, Feldman HI, Joffe MM (2009) Iron indices in chronic kidney disease in the National Health and Nutritional Examination Survey 1988–2004. Clin J Am Soc Nephrol 4:57–61
Minutolo R, Locatelli F, Gallieni M et al (2013) Anaemia management in non-dialysis chronic kidney disease (CKD) patients: a multicentre prospective study in renal clinics. Nephrol Dial Transplant 28:3035–3045
Besarab A, Horl WH, Silverberg D (2009) Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome. Oncologist 14(Suppl 1):22–33
McClellan W, Aronoff SL, Bolton WK et al (2004) The prevalence of anemia in patients with chronic kidney disease. Curr Med Res Opin 20:1501–1510
Macdougall IC (2010) Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: oral or intravenous? Curr Med Res Opin 26:473–482
Brittenham GM, Andersson M, Egli I et al (2014) Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: a randomized study. Am J Clin Nutr 100:813–820
Macdougall IC, Bock AH, Carrera F et al (2014) FIND-CKD: a randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia. Nephrol Dial Transplant 29:2075–2084
Albaramki J, Hodson EM, Craig JC, Webster AC (2012) Parenteral versus oral iron therapy for adults and children with chronic kidney disease. Cochrane Database Syst Rev. Issue 1 (Art. no. CD007857)
Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S et al (2013) Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin 29:291–303
Toblli JE, Cao G, Olivieri L, Angerosa M (2010) Comparison of the renal, cardiovascular and hepatic toxicity data of original intravenous iron compounds. Nephrol Dial Transplant 25:3631–3640
Toblli JE, Di Gennaro F (2015) Switching patients with non-dialysis chronic kidney disease from oral iron to intravenous ferric carboxymaltose: effects on erythropoiesis-stimulating agent requirements, costs, hemoglobin and iron status. PLoS One 10(4):e0125528
Minutolo R, Liberti ME, Garofalo C, et al (2015) Clinical experience with ferric carboxymaltose in non-dialysis chronic kidney disease. G Ital Nefrol 32(5) (pii: gin/32.5.11)
Protein and aminoacid requirements in human nutrition (2007) Report of a Joint FAO/WHO/UNU Expert Consultation. In: WHO technical report series 935. http://apps.who.int/iris/bitstream/10665/43411/1/WHO_TRS_935_eng.pdf. Accessed 21 July 2016
Millward DJ (1999) Optimal intakes of protein in the human diet. Proc Nutr Soc 58:403–413
Cirillo M, Lombardi C, Chiricone D, De Santo NG, Zanchetti A, Bilancio G (2014) Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data. Nephrol Dial Transplant 29:1733–1740
De Nicola L, Chiodini P, Zoccali C, Borrelli S, Cianciaruso B, Di Iorio B, SIN-TABLE CKD Study Group et al (2011) Prognosis of CKD patients receiving outpatient nephrology care in Italy. Clin J Am Soc Nephrol 6:2421–2428
KDIGO Guidelines (2013) Chapter 3. Management of progression and complications of CKD. Kidney Int 3:73–90
Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D et al (2012) Ketoacid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr 22(Suppl 2):22–24
Cianciaruso B, Pota A, Pisani A, Torraca S, Annecchini R, Lombardi P et al (2008) Metabolic effects of two low protein diets in chronic kidney disease stage IV–V: a randomized controlled trial. Nephrol Dial Transpl 23:636–644
D’Alessandro C, Piccoli GB, Calella P, Brunori G, Pasticci F, Bellizzi V et al (2016) “Dietaly”: practical issues for the nutritional management of CKD patients in Italy. BMC Nephrol (in press)
Mitch WE, Remuzzi G (2004) Diet for patients with chronic kidney disease, still worth prescribing. J Am Soc Nephrol 15:234–237
Fouque D, Laville M (2009) Low protein diets for chronic kidney disease in non-diabetic adults. Cochrane Database Syst Rev. doi:10.1002/14651858
D’Alessandro C, Rossi A, Innocenti M, Ricchiuti G, Bozzoli L, Sbragia G, Meola M, Cupisti A (2013) Dietary protein restriction for renal patients: don’t forget protein-free foods. J Ren Nutr 23(5):367–371. doi:10.1053/j.jrn.2012.12.006
Cianciaruso B, Pota A, Bellizzi V, Di Giuseppe D, Di Micco L, Minutolo R et al (2009) Effect of a low- versus moderate-protein diet on progression of CKD: follow-up of a randomized controlled trial. Am J Kidney Dis 54:1052–1061
Brunori G, Viola BF, Parrinello G, De Biase V, Como G, Franco V, Garibotto G, Zubani R, Cancarini GC (2007) Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a Prospective Randomized Multicenter Controlled Study. Am J Kidney Dis 49:569–580
Mennini FS, Russo S, Marcellusi A, Quintaliani G, Fouque D (2014) Economic effects of treatment of chronic kidney disease with low-protein diet. J Ren Nutr 24(5):313–321
Bellizzi V, Scalfi L, Terracciano V et al (2006) Early changes in bioelectrical estimates of body composition in chronic kidney disease. J Am Soc Nephrol 17(5):1481–1487
Cianciaruso B, Bellizzi V, Minutolo R et al (1996) Renal adaptation to dietary sodium restriction in moderate renal failure resulting from chronic glomerular disease. J Am Soc Nephrol 7(2):306–313
McMahon EJ, Bauer JD, Hawley CM et al (2103) Randomized trial of dietary sodium restriction in CKD. J Am Nephrol 24:2096–2103
Lambers Heerspink HJ, Holtkamp FA, Parving HH et al (2012) Moderate of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers. Kidney Int 82:330–337
Vegter S, Perna A, Postma MJ et al (2012) Sodium intake, ACE inhibition and progression to ESRD. J Am Soc Nephrol 23:165–173
He J, Katherine T. Mills KT, Appel LJ et al (2015) Urinary sodium and potassium excretion and CKD progression. J Am Soc Nephrol (pii ASN.2015010022, Epub ahead of print)
Danovitch GM, Bourgoignie J, Bricker NS (1997) Reversibility of the salt-losing tendency of chronic renal failure. N Engl J Med 296:14–19
De Nicola L, Minutolo R, Bellizzi V, Zoccali C, Cianciaruso B, Andreucci VE, Fuiano G, Conte G, for the investigators of the TArget Blood Pressure LEvels in Chronic Kidney Disease (TABLE in CKD) Study Group (2004) Achievement of target blood pressure levels in chronic kidney disease: a salty question? Am J Kidney Dis 43:782–795
Esnault VLM, Ekhlas A, Delcroix C et al (2005) Diuretic and enhanced sodium restriction in improved antiproteinuric response to RAS blocking agents. J Am Soc Nephrol 16:474–481
Raphael KL, Zhang Y, Ying J, Greene T (2014) Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease. Nephrology 19:648–654
Driver TH, Shlipak MG, Katz R et al (2014) Low serum bicarbonate and kidney function decline: the multi-ethnic study of atherosclerosis (MESA). Am J Kidney Dis 64:534–541
Dobre M, Yang W, Pan Q et al (2015) Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): a report from the Chronic Renal Insufficiency Cohort (CRIC) study. J Am Heart Ass 4:e001599
Navaneethan SD, Schold JD, Arrigain S et al (2011) Serum bicarbonate and mortality in stage 3 and stage 4 chronic kidney disease. Clin J Am Soc Nephrol 6:2395–2402
Kovesdy CP, Anderson JE, Kalantar-Zadeh K (2009) Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD. Nephrol Dial Transplant 24:1232–1237
Jeong J, Kwon SK, Kim HY (2014) Effect of bicarbonate supplementation on renal function and nutritional indices in predialysis advanced chronic kidney disease. Electrolyte Blood Press 12:80–87
Susantitapong P, Sewaralthahab K, Balk EM, Jaber BL, Madias NE (2012) Short and long term effects of alkali therapy in chronic kidney disease: a systematic review. AmJ Nephrol 35:540–547
National Kidney Foundation (2010) K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis 35(suppl 2):S1–S140
National Kidney Foundation (2003) K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 42(Suppl 3):S1–S201
Goraya N, Simoni J, Jo CH, Wesson DE (2014) Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate. Kidney Int 86:1031–1038
Goraya N, Simoni J, Jo CH, Wesson DE (2013) A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. Clin J Am Soc Nephrol 8:371–381
Barsotti G, Cupisti A, Ciardella F, Morelli E, Niosi F, Giovannetti S (1990) Compliance with protein restriction: effects on metabolic acidosis and progression of renal failure in chronic uremics on supplemented diet. Contrib Nephrol 81:42–49
de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM (2009) Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 20:2075–2084
Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE (2010) Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 78:303–309
Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab MH, Wesson DE (2010) Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR. Kidney Int 77:617–623
Kotchen TA, Kotchen JM (1997) Dietary sodium and blood pressure: interactions with other nutrients. Am J Clin Nutr 65(Suppl 1):708S–711S
Luft FC, Steinberg H, Ganten U et al (1988) Effect of sodium chloride and sodium bicarbonate on blood pressure in stroke-prone spontaneously hypertensive rats. Clin Sci (Lond) 74(6):577–585
Husted FC, Nolph KD (1977) NaHCO3 and NaCl tolerance in chronic renal failure II. Clin Nephrol 7:21–25
Witham MD, Lamb EJ (2015) Should chronic metabolic acidosis be treated in older people with chronic kidney disease? Nephrol Dial Transplant. doi:10.1093/ndt/gfv344
Raphael KL (2016) Approach to the treatment of chronic metabolic acidosis in CKD. Am J Kidney Dis. doi:10.1053/j.ajkd.2015
Kalantar-Zadeh K, Streja E, Kovesdy CP, Oreopoulos A, Noori N, Jing J, Nissenson AR, Krishnan M, Kopple JD, Mehrotra R, Anker SD (2010) The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc 85:991–1001
Kovesdy CP, Anderson JE, Kalantar-Zadeh K (2007) Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am J Kidney Dis 49:581–591
Ogorodnikova AD, Kim M, McGinn AP, Muntner P, Khan U, Wildman RP (2012) Incident cardiovascular disease events in metabolically benign obese individuals. Obesity 20:651–659
Kwan BC, Murtaugh MA, Beddhu S (2007) Associations of body size with metabolic syndrome and mortality in moderate chronic kidney disease. Clin J Am Soc Nephrol 2:992–998
Hanks LJ, Tanner RM, Muntner P, Kramer H, McClellan WM, Warnock DG, Judd SE, Gutiérrez OM, Investigators REGARDS (2013) Metabolic subtypes and risk of mortality in normal weight, overweight, and obese individuals with CKD. Clin J Am Soc Nephrol 8:2064–2071
Kramer H, Tuttle KR, Leehey D, Luke A, Durazo-Arvizu R, Shoham D et al (2009) Obesity management in adults with CKD. Am J Kidney Dis 53:151–165
Postorino M, Marino C, Tripepi G, Zoccali C, CREDIT (Calabria Registry of Dialysis and Transplantation) Working Group (2009) Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 53(15):1265–1272
Teta D (2010) Weight loss in obese patients with chronic kidney disease: who and how? J Ren Care 36(Suppl 1):163–171. doi:10.1111/j.1755-6686.2010.00176.x
Kramer H, Shoham D, McClure LA, Durazo-Arvizu R, Howard G, Judd S, Muntner P, Safford M, Warnock DG, McClellan W (2011) Association of waist circumference and body mass index with all-cause mortality in CKD: the REGARDS (reasons for geographic and racial differences in stroke) Study. Am J Kidney Dis 58:177–185
Carvalho LK, Barreto Silva MI, da Silva Vale B, Bregman R, Martucci RB, Carrero JJ, Avesani CM (2012) Annual variation in body fat is associated with systemic inflammation in chronic kidney disease patients stages 3 and 4: a longitudinal study. Nephrol Dial Transplant 27(4):1423–1428
Navaneethan SD, Kirwan JP, Arrigain S, Schreiber MJ, Sehgal AR, Schold JD (2012) Overweight, obesity and intentional weight loss in chronic kidney disease: NHANES 1999–2006. Int J Obes 36(12):1585–1590
Turgeon NA, Perez S, Mondestin M, Davis SS, Lin E, Tata S, Kirk AD, Larsen CP, Pearson TC, Sweeney JF (2012) The impact of renal function on outcomes of bariatric surgery. J Am Soc Nephrol 23(5):885–894
Navaneethan SD, Yehnert H, Moustarah F, Schreiber MJ, Schauer PR, Beddhu S (2009) Weight loss interventions in chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol 4(10):1565–1574
Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM et al (2015) Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 385(9981):1975–1982
Bargman JM (2015) Timing of initiation of RRT and modality selection. Clin J Am Soc Nephrol 10(6):1072–1077
Davison SN, Levin A, Moss AH (2015) Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care. Kidney Int 88(3):447–459
van de Luijtgaarden MW, Noordzij M, Tomson C et al (2012) Factors influencing the decision to start renal replacement therapy: results of a survey among European nephrologists. Am J Kidney Dis 60(6):940–948
Eckardt K, Gillespie I, Kronenberg F et al (2015) High cardiovascular event rates occur within the first weeks of starting hemodialysis. Kidney Int 88:1117–1125
Zareba W (2015) Initiation of dialysis: trigger or cause of cardiovascular events? Kidney Int 88:942–944
Pacilio M, Minutolo R, Garofalo C, Liberti ME, Conte G, De Nicola L (2016) Stage 5-CKD under nephrology care: to dialyze or not to dialyze, that is the question. J Nephrol 29(2):153–161
Tattersall J, Dekker F, Heimbürger O, ERBP Advisory Board et al (2011) When to start dialysis: updated guidance following publication of the Initiating Dialysis Early and Late (IDEAL) study. Nephrol Dial Transplant 26(7):2082–2086
Da Silva-Gane M, Wellsted D, Greenshields H, Norton S, Chandna SM, Farrington K (2012) Quality of life and survival in patients with advanced kidney failure managed conservatively or by dialysis. Clin J Am Soc Nephrol 7(12):2002–2009
Minutolo R, Lapi F, Chiodini P et al (2014) Risk of ESRD and death in patients with CKD not referred to a nephrologist: a 7-year prospective study. Clin J Am Soc Nephrol 9(9):1586–1593
Borrelli S, Leonardis D, Minutolo R et al (2015) Epidemiology of CKD regression in patients under nephrology care. PLoS One 10(5):e0127071
De Nicola L, Provenzano M, Chiodini P et al (2015) Independent role of underlying kidney disease on renal prognosis of patients with chronic kidney disease under nephrology care. PLoS One 10(10):e0140138
Scalone L, Borghetti F, Brunori G et al (2010) Cost-benefit analysis of supplemented very low-protein diet versus dialysis in elderly CKD5 patients. Nephrol Dial Transplant 25(3):907–913
Kerr M, Bray B, Medcalf J, O’Donoghue DJ, Matthews B (2012) Estimating the financial cost of chronic kidney disease to the NHS in England. Nephrol Dial Transplant 27(S3):73–80
Viglino G, Neri L, Barbieri S (2008) Incremental peritoneal dialysis: effects on the choice of dialysis modality, residual renal function and adequacy. Kidney Int Suppl 108:S52–S55
Wong J, Vilar E, Davenport A, Farrington K (2015) Incremental haemodialysis. Nephrol Dial Transplant 30(10):1639–1648
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Bellizzi, V., Conte, G., Borrelli, S. et al. Controversial issues in CKD clinical practice: position statement of the CKD-treatment working group of the Italian Society of Nephrology. J Nephrol 30, 159–170 (2017). https://doi.org/10.1007/s40620-016-0338-x
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DOI: https://doi.org/10.1007/s40620-016-0338-x