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Age-related blunting of the phagocyte arsenal and its art of killing

  • Molecular Biology of Cell Death and Aging (N Razdan and N Muhammad, Section Editors)
  • Published:
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Abstract

Phagocytosis is one of the integral parts of the host defense mechanism employed against invading pathogens. Cells which can sense and identify a pathogenic signal and can clear it by virtue of phagocytosis-dependent cell killing are known as phagocytes. Another important function of phagocytes is the removal of apoptotic cells, crucial for maintaining tissue homeostasis. However, these essential functions of phagocytes declined with age, leading toward age-dependent immune dysfunction. In this article, we have reviewed a detailed mechanistic approach of the phagocytosis process, in the context of the age-dependent alterations of this phenomenon.

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Abbreviations

PAMPS:

Pathogen-associated molecular patterns

DAMPS:

Damage-associated molecular pattern

PICD:

Pathogen-induced cell death

DC:

Dendritic cells

MARCO:

The macrophage receptor with collagenous structure

PRE:

Pigment epithelial cells

CRs:

Complement receptors

LPC:

Lysophosphatidylcholine

L1P:

Sphingosine-1-phosphate

CRT:

Calreticulin

BAI1:

Brain-specific angiogenesis inhibitor 1

TIM:

T cell immunoglobulin mucin

NETs:

Neutrophil extracellular traps

MCAF:

Macrophage chemotactic and activating factor

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Authors and Affiliations

  1. Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam, 784028, India

    Anindhya Sundar Das

  2. Department of Physiology, University of Calcutta, Kolkata, 700090, India

    Roshnara Mishra

  3. Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, MO, 63110, USA

    Sourav Bhattacharya

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  1. Anindhya Sundar Das
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Das, A.S., Mishra, R. & Bhattacharya, S. Age-related blunting of the phagocyte arsenal and its art of killing. Curr Mol Bio Rep 6, 126–138 (2020). https://doi.org/10.1007/s40610-020-00135-y

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