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Molecular Control of Growth-Related Sodium-Phosphate Co-transporter (SLC34A3)

  • Molecular Control of Phosphorus Homeostasis (B van der Eerden, Section Editor)
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Abstract

The type IIa sodium-dependent inorganic phosphate transporter (NaPi-IIa) has a central regulatory role in inorganic phosphate (Pi) homeostasis. Many studies have reported on the functions and regulatory mechanisms of NaPi-IIa. NaPi-IIc, however, was initially identified as a NaPi transporter required for growth in rodents. The gene encoding NaPi-IIc is causative for hereditary hypophosphatemic rickets with hypercalciuria and considered to be a critical NaPi transporter in the human kidney. However, the physiological roles and regulatory mechanisms of NaPi-IIc are not sufficiently elucidated. Recent studies show that NaPi-IIc is tightly regulated by a variety of agonists and physiological conditions via partially defined molecular mechanisms, including transcriptional and posttranscriptional regulation, protein phosphorylation, trafficking (endocytosis, exocytosis, and recycling), and the association of NaPi-IIc with interacting protein complexes. These data provide further information about understanding of human renal Pi handling. Here, we review recent findings regarding the molecular control of NaPi-IIc transporters.

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Funding

This study was funded in part by the Ministry of Education, Culture, Sports, Science, and Technology of Japan (No. 23689045 to H. Segawa, No. 26293204 to K. Miyamoto), and the Salt Science Research Foundation (No. 1322 to K. Miyamoto).

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Authors and Affiliations

  1. Department of Molecular Nutrition, University of Tokushima Graduate School, Tokushima, Japan

    Hiroko Segawa, Ichiro Kaneko, Yuji Shiozaki, Sawako Tatsumi & Ken-Ichi Miyamoto

  2. Department of Molecular Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima City, 770-8503, Japan

    Hiroko Segawa & Ken-Ichi Miyamoto

  3. Human Science and Environment, University of Hyogo Graduate School, Hyogo, Japan

    Mikiko Ito

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  1. Hiroko Segawa
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  2. Ichiro Kaneko
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  5. Sawako Tatsumi
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  6. Ken-Ichi Miyamoto
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Correspondence to Hiroko Segawa or Ken-Ichi Miyamoto.

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Hiroko Segawa, Ichiro Kaneko, Yuji Shiozaki, Mikiko Ito, Sawako Tatsumi, and Ken-Ichi Miyamoto each declare no potential conflicts of interest.

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Segawa, H., Kaneko, I., Shiozaki, Y. et al. Molecular Control of Growth-Related Sodium-Phosphate Co-transporter (SLC34A3). Curr Mol Bio Rep 5, 26–33 (2019). https://doi.org/10.1007/s40610-019-0112-7

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