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Limitations on the Multiplicity of Cellular Infection During Human Alphaherpesvirus Disease

  • Virology (A Nicola, Section Editor)
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Abstract

Purpose of Review

Nearly every human is persistently infected with one of three alphaherpesviruses: herpes simplex virus-1, herpes simplex virus-2, and varicella zoster virus. Infection elicits diseases ranging from epithelial lesions to viral encephalitis. Recurrent alphaherpesvirus-associated diseases result from transmission of infection from neurons. The number of viruses that productively infects a cell defines an important property known as the multiplicity of cellular infection (MOCI). The rates at which alphaherpesviruses replicate within cells, spread infection between cells, and elicit recurrent diseases are directly impacted by the MOCI.

Recent Findings

Several studies have quantified the MOCI during alphaherpesvirus infection. There is evidence that two limiting factors impact various aspects of alphaherpesvirus MOCI and directly affect pathogenesis. Those limitations include a limit on the number of viral genomes that can replicate within a host cell and a limit on cellular superinfection.

Summary

This review will detail what is known about the limitations that affect MOCI and how it shapes alphaherpesvirus spread and disease.

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  1. Department of Microbiology & Immunology, 211 Cooley Laboratory, Montana State University, Bozeman, MT, 59717, USA

    Alix E. Herr, Kyle S. Hain & Matthew P. Taylor

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  1. Alix E. Herr
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  2. Kyle S. Hain
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Herr, A.E., Hain, K.S. & Taylor, M.P. Limitations on the Multiplicity of Cellular Infection During Human Alphaherpesvirus Disease. Curr Clin Micro Rpt 4, 167–174 (2017). https://doi.org/10.1007/s40588-017-0071-9

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