Abstract
Introduction
It is important to understand the anesthetic requirements of elderly patients. However, little is known about age-related recovery from inhalational anesthetics. In this retrospective study, we compared age-related differences in recovery from three inhalational anesthetics in elderly subjects.
Methods
Patients were investigated as three age groups which can be defined as age ranges pediatric (< 15 years), adult (15–64 years), and elderly patients ( > 65 years) under general anesthesia using inhalational anesthetics. Anesthesia and surgery times, drug end-tidal concentrations, the time to first movement, time to eye opening, body movement, extubation, and discharge were recorded. The data were analyzed using a Kruskal–Wallis test and Steel–Dwass multiple comparisons.
Results
A total of 594 patients were included in the study. In inhalational anesthetics such as sevoflurane, isoflurane, or desflurane, recovery from general anesthesia was not significantly different among age groups (P > 0.05). In inhalational group, recovery was significantly 5–40% faster in desflurane group than in other inhalational anesthetics groups (P < 0.05). There were 20% faster recovery in pediatric and adult groups with desflurane than in elderly with desflurane group. Drug end-tidal inhalational concentrations in pediatric group were significantly higher than that in adult and elderly groups of all inhalational anesthetics, respectively (P < 0.05).
Conclusion
In the current study, we have found that recovery from desflurane was faster in younger patients than in other inhalational anesthetics and aged patients.
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We have no conflict of interest.
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The Ethic Review Board of Kyushu University Hospital approved a retrospective study.
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For this kind of study informed consent is not rquired.
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Tsukamoto, M., Yamanaka, H. & Yokoyama, T. Age-related differences in recovery from inhalational anesthesia: a retrospective study. Aging Clin Exp Res 30, 1523–1527 (2018). https://doi.org/10.1007/s40520-018-0924-y
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DOI: https://doi.org/10.1007/s40520-018-0924-y