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New-generation Antipsychotics and Cardiovascular Risk

  • Schizophrenia and Other Psychotic Disorders (J Csernansky, Section Editor)
  • Published:
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Abstract

Purpose of Review

To critically review the current landscape of literature on cardiotoxicity of “new-generation antipsychotics,” defined as those approved by the Food and Drug Administration in the last 10 years.

Recent Findings

There is a paucity of data regarding the cardiovascular risks of these medications. Based on the investigations that have been published, iloperidone appears to be the greatest risk of corrected QT prolongation followed by asenapine whereas lurasidone, cariprazine, and brexpiprazole were not found to have significant effects on corrected QT. However, the evidence was low quality. In terms of metabolic effects, asenapine, iloperidone, cariprazine, and brexpiprazole all had mild to moderate effects whereas lurasidone had no significant effects observed.

Summary

Further investigation is warranted for all of these medications to better understand their cardiovascular effects.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Acknowledgments

We would like to acknowledge Elaine Alligood for her assistance in literature search and article access.

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Authors and Affiliations

  1. Department of Veterans Affairs, 940 Belmont St., Bld 5, 116-A7, Brockton, MA, 02301, USA

    Aishwarya K. Rajagopalan DO, MHS, William K. Bache MD, Serena Z. Chen MD, Ermal Bojdani MD & Kevin J. Li MD

  2. Harvard South Shore Psychiatry Residency Training Program, Brockton, MA, USA

    Aishwarya K. Rajagopalan DO, MHS, William K. Bache MD, Serena Z. Chen MD, Ermal Bojdani MD & Kevin J. Li MD

  3. Harvard Medical School, Boston, MA, USA

    Aishwarya K. Rajagopalan DO, MHS, William K. Bache MD, Serena Z. Chen MD, Ermal Bojdani MD & Kevin J. Li MD

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Correspondence to Kevin J. Li MD.

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Aishwarya K. Rajagopalan, William K. Bache, Serena Z. Chen, Ermal Bojdani, and Kevin J. Li declare that they have no conflict of interest.

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Rajagopalan, A.K., Bache, W.K., Chen, S.Z. et al. New-generation Antipsychotics and Cardiovascular Risk. Curr Treat Options Psych 6, 154–163 (2019). https://doi.org/10.1007/s40501-019-00173-z

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