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Mild Hyperuricemia: To Treat, or Not to Treat, That is the Question. Suggestions form the URRAH Study

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References

  1. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund O, ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111–88. https://doi.org/10.1093/eurheartj/ehz455PMID: 31504418.

    Article  PubMed  Google Scholar 

  2. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I. Authors/task force members: 2018 ESC/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953–2041. https://doi.org/10.1097/HJH.0000000000001940Erratum. In: J Hypertens. 2019 Jan; 37(1):226 PMID: 30234752.

    Article  CAS  PubMed  Google Scholar 

  3. Borghi C, Rosei EA, Bardin T, Dawson J, Dominiczak A, Kielstein JT, Manolis AJ, Perez-Ruiz F, Mancia G. Serum uric acid and the risk of cardiovascular and renal disease. J Hypertens. 2015;33(9):1729–41. https://doi.org/10.1097/HJH.0000000000000701PMID: 26136207; discussion 1741.

    Article  CAS  PubMed  Google Scholar 

  4. Maloberti A, Giannattasio C, Bombelli M, Desideri G, Cicero AFG, Muiesan ML, Rosei EA, Salvetti M, Ungar A, Rivasi G, Pontremoli R, Viazzi F, Facchetti FC, Bernardino B, Galletti F, Delia L, Palatini P, Casiglia E, Tikhonoff V, Barbagallo CM, Verdecchia P, Masi S, Mallamaci F, Cirillo M, Rattazzi M, Pauletto P, Cirillo P, Gesualdo L, Mazza A, Volpe M, Tocci G, Iaccarino G, Nazzaro P, Lippa L, Parati G, Delloro R, Quarti-Trevano F, Grassi G, Virdis A, Borghi C, Working Group on Uric Acid, and Cardiovascular Risk of the Italian Society of Hypertension (SIIA). Hyperuricemia and risk of cardiovascular outcomes: the experience of the URRAH (Uric Acid Right for Heart Health) project. High Blood Press Cardiovasc Prev. 2020. https://doi.org/10.1007/s40292-020-00368-z.

    Article  PubMed  Google Scholar 

  5. Virdis A, Masi S, Casiglia E, Tikhonoff V, Cicero AFG, Ungar A, Rivasi G, Salvetti M, Barbagallo CM, Bombelli M, Dell'Oro R, Bruno B, Lippa L, D'Elia L, Verdecchia P, Mallamaci F, Cirillo M, Rattazzi M, Cirillo P, Gesualdo L, Mazza A, Giannattasio C, Maloberti A, Volpe M, Tocci G, Georgiopoulos G, Iaccarino G, Nazzaro P, Parati G, Palatini P, Galletti F, Ferri C, Desideri G, Viazzi F, Pontremoli R, Muiesan ML, Grassi G, Borghi C, From the Working Group on Uric Acid, and Cardiovascular Risk of the Italian Society of Hypertension. Identification of the uric acid thresholds predicting an increased total and cardiovascular mortality over 20 years. Hypertension. 2020;75(2):302–8. https://doi.org/10.1161/HYPERTENSIONAHA.119.13643.

    Article  CAS  PubMed  Google Scholar 

  6. Casiglia E, Tikhonoff V, Virdis A, Masi S, Barbagallo CM, Bombelli M, Bruno B, Cicero AFG, Cirillo M, Cirillo P, Desideri G, Delia L, Ferri C, Galletti F, Gesualdo L, Giannattasio C, Iaccarino G, Lippa L, Mallamaci F, Maloberti A, Mazza A, Muiesan ML, Nazzaro P, Palatini P, Parati G, Pontremoli R, Quarti-Trevano F, Rattazzi M, Rivasi G, Salvetti M, Tocci G, Ungar A, Verdecchia P, Viazzi F, Volpe M, Grassi G, Borghi C, Working Group on Uric Acid, and Cardiovascular Risk of the Italian Society of Hypertension (SIIA). Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: the URRAH (uric acid right for heart health) study. J Hypertens. 2020;38(3):412–9. https://doi.org/10.1097/HJH.0000000000002287.

    Article  CAS  PubMed  Google Scholar 

  7. Li X, Meng X, Timofeeva M, Tzoulaki I, Tsilidis KK, Ioannidis JP, Campbell H, Theodoratou E. Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies. BMJ. 2017;7(357):j2376. https://doi.org/10.1136/bmj.j2376Erratum. In: BMJ. 2017 Aug 8;358: j3799. PMID: 28592419; PMCID: PMC5461476.

    Article  Google Scholar 

  8. Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol. 2015;77:323–45. https://doi.org/10.1146/annurev-physiol-021113-170343Epub 2014 Nov 12 PMID: 25422986.

    Article  CAS  PubMed  Google Scholar 

  9. Menè P, Punzo G. Uric acid: bystander or culprit in hypertension and progressive renal disease? J Hypertens. 2008;26(11):2085–92. https://doi.org/10.1097/HJH.0b013e32830e4945PMID: 18854744.

    Article  CAS  PubMed  Google Scholar 

  10. Cappuccio FP, Strazzullo P, Farinaro E, Trevisan M. Uric acid metabolism and tubular sodium handling. Results from a population-based study. JAMA. 1993;270(3):354–9 PMID: 8315780.

    Article  CAS  Google Scholar 

  11. Toyoki D, Shibata S, Kuribayashi-Okuma E, Xu N, Ishizawa K, Hosoyamada M, Uchida S. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. Am J Physiol Renal Physiol. 2017;313(3):F826–F834834. https://doi.org/10.1152/ajprenal.00012.2017Epub 2017 Jul 5 PMID: 28679589.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine (DIMED), University of Padua, via S. Mattia 20, 35121, Padua, Italy

    Andrea Semplicini

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  1. Andrea Semplicini
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Correspondence to Andrea Semplicini.

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Semplicini, A. Mild Hyperuricemia: To Treat, or Not to Treat, That is the Question. Suggestions form the URRAH Study. High Blood Press Cardiovasc Prev 27, 119–120 (2020). https://doi.org/10.1007/s40292-020-00376-z

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