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Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase

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Abstract

Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.

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Authors and Affiliations

  1. Institute of Wudang Traditional Chinese Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

    Tao Zheng, Li Chen & Qibin Wang

  2. Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China

    Fang Bian

  3. Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China

    Si Jin

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  1. Tao Zheng
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SJ and TZ conceived and designed the study. TZ, FB, LC, QW and SJ reviewed the data, drew the figure and wrote the manuscript.

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Correspondence to Si Jin.

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TZ, FB, LC, QW and SJ have no conflicts of interest that are directly relevant to the content of this article.

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This work was supported by grants from the National Natural Science Foundation of China (81703582, 81573432, 81503072 and 81373413), Ministry of Education of China (NCET-10-0409), and Hubei Provincial Natural Science Foundation of China (2016CFB153).

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Zheng, T., Bian, F., Chen, L. et al. Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase. Mol Diagn Ther 23, 489–498 (2019). https://doi.org/10.1007/s40291-019-00402-4

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