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The Null Polymorphism of the GSTM1/T1 Gene Is Not Associated with Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis

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Abstract

Previous studies have suggested that the null polymorphism of the glutathione S-transferases M1/T1 (GSTM1/T1) gene may be associated with the risk of developing systemic lupus erythematosus (SLE). We further explored this potential association using a meta-analysis. A systematic literature search was carried out in the scientific literature databases and we used odds ratios (OR) and 95 % confidence intervals (CIs) to evaluate the strength of this association. All statistical analyses were calculated using Stata software 11.0, and Bonferroni correction was used to adjust the p values. Nine eligible articles with 1,850 patients and 2,826 controls were identified. Our results showed the null polymorphism of the GSTM1 gene was associated with SLE in East Asians (OR 1.32, 95 % CI 1.04–1.69, p = 0.024), but not in Europeans and Africans. However, when Bonferroni corrections were applied (p = 0.05/2 = 0.025), we could not be sure of this association. We further analysed the associations between the GSTT1 gene null polymorphism and the risk of SLE. The results of this investigation showed that this null polymorphism was not associated with susceptibility to SLE in all included populations. In conclusion, the null polymorphism of GSTM1/T1 gene may not be associated with the risk of SLE. More studies are needed to confirm this lack of association between key oxidative defense genes and susceptibility to SLE in the future.

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Acknowledgments

Supported by the Natural Science Fund of Yunnan Province (No. 2013FB044, No. 2014FB008) and the Education Department Fund of Yunnan Province (No. 2014Y165). The authors acknowledge the editors and reviewers for their positive and constructive comments and suggestions on our study.

Conflict of interest

The authors have no conflict of interest.

Author Contributions

Conceived and designed the experiments: Li He and Lechun Lu. Performed the experiments: Lechun Lu, Dongyun Lei, Xiang Nong, Meihua Guo, and Jiaqing Ma. Analyzed the data: Lechun Lu, Dongyun Lei. Wrote the paper: Lechun Lu, Dongyun Lei, and Li He.

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    Authors and Affiliations

    1. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan 650032, China

      Lechun Lu, Dongyun Lei, Xiang Nong & Li He

    2. Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China

      Lechun Lu

    3. Division of Science and Research, Kunming Medical University, Kunming, Yunnan, China

      Meihua Guo

    4. Center of Functional Experiment, Kunming Medical University, Kunming, Yunnan, China

      Jiaqing Ma

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    1. Lechun Lu
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    2. Dongyun Lei
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    3. Xiang Nong
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    4. Meihua Guo
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    5. Jiaqing Ma
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    6. Li He
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    Corresponding author

    Correspondence to Li He.

    Additional information

    L. Lu, D. Lei and X. Nong contributed equally to this work and should be considered joint first authors.

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    Lu, L., Lei, D., Nong, X. et al. The Null Polymorphism of the GSTM1/T1 Gene Is Not Associated with Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis. Mol Diagn Ther 19, 65–69 (2015). https://doi.org/10.1007/s40291-015-0131-x

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    • DOI: https://doi.org/10.1007/s40291-015-0131-x

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