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Recent Development of DNA-modified AIEgen Probes for Biomedical Application

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Chemical Research in Chinese Universities Aims and scope

Abstract

A variety of DNA-based probes are utilized for the detections of multiple analytes and DNA nanotechnology has been thriving for recent decades and achieving numerous nanostructures, mainly focusing on DNA morphology modulation and multifunctional systems engineered into to the complicated works. Among the numerous detections, fluorescence method is a non-invasive, highly selective and sensitive means for varieties of applications, but their emissions are often compromised by the aggregation-caused quenching(ACQ) effect, which weakens their applications. The aggregation induced emission luminogens(AIEgens) are created with non emissive or weakly emissive in a low concentration but emit strong fluorescence in a high concentration with aggregated states. Herein, numerous functionalized AIEgens have been emerged and used for detection and imaging and DNA-modified AIEgen probes are introduced. In this vein, here we report the progress on DNA-modified AIEgen probes in recent years and highlight their conjugation strategies including covalent bonding, electrostatic interaction and their applications of biosensing. Moreover, multiple DNA strands are needed to introduce into the DNA-modified AIEgen probes for more purposes. At the end, some challenges are mentioned to discuss the new trend of DNA-modified AIEgen probes.

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Acknowledgements

This work was supported by the National Key R&D Program of China (No. 2020YFA0211200), the National Natural Science Foundation of China(Nos. 21974128, 21874121), the Natural Science Foundation of Hubei Province, China(No.2019CFA043), and supported by the Open Research Fund of the State Key Laboratory of Bioelectronics(Southeast University), China and the Hubei Postdoctoral Innovative Research Foundation, China(to Wu Jun), and the Project Funded by China Postdoctoral Science Foundation(No.2020M672436).

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Authors and Affiliations

  1. Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China

    Qinyu Hu, Jun Wu, Lulu Chen, Xiaoding Lou & Fan Xia

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  1. Qinyu Hu
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  2. Jun Wu
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  3. Lulu Chen
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  4. Xiaoding Lou
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  5. Fan Xia
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Correspondence to Xiaoding Lou.

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Hu, Q., Wu, J., Chen, L. et al. Recent Development of DNA-modified AIEgen Probes for Biomedical Application. Chem. Res. Chin. Univ. 37, 66–72 (2021). https://doi.org/10.1007/s40242-021-0388-z

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  • DOI: https://doi.org/10.1007/s40242-021-0388-z

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