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One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

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Abstract

An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid(DMXAA) was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.

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Authors and Affiliations

  1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China

    Zhenlei Jiang, Jie Liu, Fan Zhou, Jianrun Zhang, Zhijun Liu, Chao Zhang & Heru Chen

  2. Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen, 518020, P. R. China

    Jie Liu

  3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou, 510632, P. R. China

    Heru Chen

Authors
  1. Zhenlei Jiang
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  2. Jie Liu
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  3. Fan Zhou
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  4. Jianrun Zhang
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  5. Zhijun Liu
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  6. Chao Zhang
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  7. Heru Chen
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Corresponding author

Correspondence to Heru Chen.

Additional information

Supported by the National Natural Science Foundation of China(No.81172982) and the Natural Science Foundation of Guangdong Province, China(No.2015A030311012).

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Jiang, Z., Liu, J., Zhou, F. et al. One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA. Chem. Res. Chin. Univ. 34, 918–922 (2018). https://doi.org/10.1007/s40242-018-8148-4

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  • DOI: https://doi.org/10.1007/s40242-018-8148-4

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