Skip to main content
SpringerLink
Log in

co-condensation synthesis of salicylaldimine calcium complex containing mesoporous silica nanoparticles as carriers for drug release

  • Published:
Chemical Research in Chinese Universities Aims and scope

Abstract

A series of functional mesoporous silica nanoparticles(MSNs) was synthesized by a one-step simple synthesis approach involving co-condensation of tetraethoxysilane(TEOS) and salicylaldimine ligand(Sal-Si) in the presence of cetyltrimethylammonium chloride(CTAC) under basic conditions. The target MSNs with different sizes (50, 100 and 200 nm, respectively) were obtained. Furthermore, the Ca2+ cations were also introduced into MSNs. The prepared nanoparticles were characterized by means of infrared(IR) spectra, thermogravimetric analysis(TGA), inductively coupled plasma(ICP), CHN elemental analysis, nitrogen adsorption-desorption, scanning electron microscope( SEM) and transmission electron microscope(TEM). Ibuprofen(IBU) which contains carboxyl groups was selected as a model drug. The results of drug loading and release reveal that the loading capacities and release behaviors of the model drug are highly dependent on the Ca2+ cations in MSNs. The release of IBU from the MSNs functionalized by Ca2+ cations is found to be effectively controlled when compared to the release from the MSNs without the functionalization of Ca2+ cations, which is due to the ionic interaction between carboxyl groups in IBU and Ca2+ cations in MSNs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ruiz-Hitzky E., Darder M., Aranda P., Ariga K., Adv. Mater., 2010, 22, 323

    Article  CAS  Google Scholar 

  2. De M., Ghosh P. S., Rotello V. M., Adv. Mater., 2008, 20, 4225

    Article  CAS  Google Scholar 

  3. Son S. J., Bai X., Lee S. B., Drug Discovery Today, 2007, 12, 650

    Article  CAS  Google Scholar 

  4. Vallet-Regi M., Colilla M., Gonzalez B., Chem. Soc. Rev., 2011, 40, 596

    Article  CAS  Google Scholar 

  5. Arcos D., Lopez-Noriega A., Ruiz-Hernandez E., Terasaki O., Vallet-Regi M., 2009, 21, 1000

    CAS  Google Scholar 

  6. de Cock L. J., de Koker S., de Geest B. G., Grooten J., Vervaet C., Remon J. P., Sukhorukov G. B., Antipina M. N., Angew. Chem. Int. Ed., 2010, 49, 6954

    Article  Google Scholar 

  7. Li Z. Z., Wen L. X., Shao L., Chen J. F. J., J. Controlled Release, 2004, 98, 245

    Article  CAS  Google Scholar 

  8. Rosler A., Vandermeulen G. W. M., Klok H. A., Adv. Drug Deliv. Rev., 2001, 53, 95

    Article  CAS  Google Scholar 

  9. Lin C. X., Qiao S. Z., Yu C. Z., Ismadji S., Lu G. Q., Microporous Mesoporous Mater., 2009, 117, 213

    Article  CAS  Google Scholar 

  10. Begu S., Pouessel A. A., Lerner D. A., Tourne-Peteilh C., Devoisselle J. M., J., Controlled Release, 2007, 118, 1

    Article  CAS  Google Scholar 

  11. Bernardos A., Aznar E., Coll C., Martinez-Manez R., Barat M. J., Dolores Marcos M., Sancenon F., Benito A., Soto J., J. Controlled Release, 2008, 131, 181

    Article  CAS  Google Scholar 

  12. Bikram M., Gobin A. M., Whitmire R. E., West J. L., J. Controlled Release, 2007, 123, 219

    Article  CAS  Google Scholar 

  13. Doadrio A. L., Sousa E. M. B., Doadrio J. C., Pariente J. P., Izquierdo-Barba I., Vallet-Regi M., J. Controlled Release, 2004, 97, 125

    Article  CAS  Google Scholar 

  14. Ginebra M. P., Traykova T., Planell J. A., J. Controlled Release, 2006, 113, 102

    Article  CAS  Google Scholar 

  15. Liu Z., Sun X., Nakayama-Ratchford N., Dai H., Acs Nano, 2007, 1, 50

    Article  Google Scholar 

  16. Hilder T. A., Hill J. M., Small, 2009, 5, 300

    Article  CAS  Google Scholar 

  17. Son S. J., Bai X., Nan A., Ghandehari H., Lee S. B., J. Controlled Release, 2006, 114, 143

    Article  CAS  Google Scholar 

  18. Kapoor M. P., Vinu A., Fujii W., Kimura T., Yang Q. H., Kasama Y., Yanagi M., Juneja L. R., Microporous Mesoporous Mater., 2010, 128, 187

    Article  CAS  Google Scholar 

  19. Yan E. Y., Fu Y. L., Wang X., Ding Y., Qian H. Q., Wang C. H., Hu Y., Jiang X. Q., J. Mater. Chem., 2011, 21, 3147

    Article  CAS  Google Scholar 

  20. Song S. W., Hidajat K., Kawi S., Langmuir, 2005, 21, 9568

    Article  CAS  Google Scholar 

  21. Fang X. S., Zhai T. Y., Gautam U. K., Li L., Wu L. M., Bando Y., Golberg D., Progress in Materials Science, 2011, 56, 175

    Article  CAS  Google Scholar 

  22. He Q. J., Shi J. L., J. Mater. Chem., 2011, 21, 5845

    Article  CAS  Google Scholar 

  23. Slowing I. I., Vivero-Escoto J. L., Wu C. W., Lin V. S. Y., Adv. Drug Deliv. Rev., 2008, 60, 1278

    Article  CAS  Google Scholar 

  24. Zhang Y., Zhi Z., Jiang T., Zhang J., Wang Z., Wang S., J. Controlled Release, 2010, 145, 257

    Article  CAS  Google Scholar 

  25. Horcajada P., Serre C., Maurin G., Ramsahye N. A., Balas F., Vallet-Regi M., Sebban M., Taulelle F., Ferey G., J. Am. Chem. Soc., 2008, 130, 6774

    Article  CAS  Google Scholar 

  26. Xia W., Chang J., J. Controlled Release, 2006, 110, 522

    Article  CAS  Google Scholar 

  27. Tang Q., Xu Y., Wu D., Sun Y., Wang J., Xu J., Deng F., J. Controlled Release, 2006, 114, 41

    Article  CAS  Google Scholar 

  28. Chen K. L., Zhao Y. H., Yuan X. Y., Chem. Res. Chinese Universities, 2014, 30(2), 339

    Article  Google Scholar 

  29. Coll C., Mondragon L., Martinez-Manez R., Sancenon F., Marcos M. D., Soto J., Amoros P., Perez-Paya E., Angew. Chem. Int. Ed., 2011, 50, 2138

    Article  CAS  Google Scholar 

  30. Bernardos A., Mondragon L., Aznar E., Marcos M. D., Martinez-Manez R., Sancenon F., Soto J., Barat J. M., Perez-Paya E., Guillem C., Amoros P., Acs Nano, 2010, 4, 6353

    Article  CAS  Google Scholar 

  31. Climent E., Martinez-Manez R., Sancenon F., Marcos M. D., Soto J., Maquieira A., Amoros P., Angew. Chem. Int. Ed., 2010, 49, 7281

    Article  CAS  Google Scholar 

  32. Lopez-Noriega A., Arcos D., Vallet-Regi M., Chem. Eur. J., 2010, 16, 10879

    Article  CAS  Google Scholar 

  33. Nieto A., Colilla M., Balas F., Vallet-Regi M., Langmuir, 2010, 26, 5038

    Article  CAS  Google Scholar 

  34. Kaluderovic G. N., Perez-Quintanilla D., Sierra I., Prashar S., del Hierro I., Zizak Z., Juranic Z. D., Fajardo M., Gomez-Ruiz S., J. Mater. Chem., 2010, 20, 806

    Article  CAS  Google Scholar 

  35. Schmidt H. T., Gray B. L., Wingert P. A., Ostafin A. E., Chem. Mater., 2004, 16, 4942

    Article  CAS  Google Scholar 

  36. Manzano M., Vallet-Regi M., J. Mater. Chem., 2010, 20, 5593

    Article  CAS  Google Scholar 

  37. Jain S. K., Awasthi A. M., Jain N. K., Agrawal G. P., J. Controlled Release, 2005, 107, 300

    Article  CAS  Google Scholar 

  38. Li H., Chang J., J. Controlled Release, 2005, 107, 463

    Article  CAS  Google Scholar 

  39. Biondi M., Ungaro F., Quaglia F., Netti P. A., Adv. Drug Deliv. Rev., 2008, 60, 229

    Article  CAS  Google Scholar 

  40. Katz E., Willner I., Angew. Chem. Int. Ed., 2004, 43, 6042

    Article  CAS  Google Scholar 

  41. Wang S. B., Microporous Mesoporous Mater., 2009, 117, 1

    Article  CAS  Google Scholar 

  42. Shylesh S., Wagner A., Seifert A., Ernst S., Thiel W. R., Chem. Eur. J., 2009, 15, 7052

    Article  CAS  Google Scholar 

  43. Ray S., Mapolie S. F., Darkwa J., J. Mol. Catal. A: Chem., 2007, 267, 143

    Article  CAS  Google Scholar 

  44. Gupta K. C., Sutar A. K., Coord. Chem. Rev., 2008, 252, 1420

    Article  CAS  Google Scholar 

  45. Bhadbhade M. M., Srinivas D., Inorg. Chem., 1993, 32, 5458

    Article  CAS  Google Scholar 

  46. Li X., Zhang L. X., Dong X. P., Liang J., Shi J. L., Microporous Mesoporous Mater., 2007, 102, 151

    Article  CAS  Google Scholar 

  47. Ruiz-Hitzky E., Darder M., Aranda P., Ariga K., Adv. Mater., 2010, 22, 323

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Duihai Tang, Weiran Zhang, Yifan Wang, Jing Miao, Zhen’an Qiao, Qisheng Huo & Lirong Zhang

Authors
  1. Duihai Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Weiran Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yifan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jing Miao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhen’an Qiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qisheng Huo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lirong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lirong Zhang.

Additional information

Supported by the National Natural Science Foundation of China(Nos. 21371067, 21171064).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tang, D., Zhang, W., Wang, Y. et al. co-condensation synthesis of salicylaldimine calcium complex containing mesoporous silica nanoparticles as carriers for drug release. Chem. Res. Chin. Univ. 30, 531–537 (2014). https://doi.org/10.1007/s40242-014-4097-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40242-014-4097-8

Keywords

Search

Navigation