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One-pot copper nanoparticle-catalyzed synthesis of imidazo[1,2-a]pyridines under solvent-free conditions

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Abstract

A direct and efficient approach to synthesize imidazo[1,2-a]pyridines through three-component one-pot reaction of 2-aminopyridine, aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed. This method provides a rapid access to substituted imidazo[1,2-a]pyridines with good yields(up to 85%).

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Authors and Affiliations

  1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China

    Chenglong Zong, Runsheng Zeng & Jianping Zou

Authors
  1. Chenglong Zong
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  2. Runsheng Zeng
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  3. Jianping Zou
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Corresponding author

Correspondence to Runsheng Zeng.

Additional information

Supported by the National Natural Science Foundation of China(Nos.20772088, 21172163) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Zong, C., Zeng, R. & Zou, J. One-pot copper nanoparticle-catalyzed synthesis of imidazo[1,2-a]pyridines under solvent-free conditions. Chem. Res. Chin. Univ. 30, 632–638 (2014). https://doi.org/10.1007/s40242-014-3520-5

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  • DOI: https://doi.org/10.1007/s40242-014-3520-5

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