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Quercetin prevents insulin dysfunction in hypertensive animals

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Abstract

Angiotensin II induced increase in hypertension enhances oxidative stress and compromises insulin action and pancreatic function. Quercetin-rich foods are beneficial for hypertensive and diabetic animals owing to their antioxidant function. The aim of this study was to evaluate the antioxidant effects of quercetin in hypertensive rats on insulin action, signaling, and secretion. Wistar rats were randomly divided into three groups: sham, hypertensive rats (H), and hypertensive rats supplemented with quercetin (HQ). After three months of initial hypertension, quercetin was administered at 50 mg/kg/day for 30 days. Our results indicate that hypertension and serum lipid peroxidation levels were reduced by quercetin supplementation. We observed increased insulin sensitivity in adipose tissue, corroborating the insulin tolerance test, HOMA index, and improvements in lipid profile. Despite normal insulin secretion at 2.8 and 20 mM of glucose, animals treated with quercetin exhibited increased number of islets per section; increased protein expression of muscarinic receptor type 3, VEGF, and catalase in islets; and hepatic mRNA levels of Ide were normalized. In conclusion, supplementation with quercetin improved insulin action and prevented pancreatic and metabolic dysfunction.

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Acknowledgments

The authors are grateful to Bruno Alves Cia, BSc, Sr Mateus Eduardo Bortolanza da Silva, Sra Ana Cristina Pires Menegheti, Renata Barbieri, and Lucas Eduardo Orzari for their excellent technical assistance.

Funding

This work was supported by a grant from the Herminio Ometto Foundation.

C. A. Serra was the recipient of a graduate fellowship grant from the Biomedical Sciences Graduate Program, FHO.

C. S. Bueno and S. A. R. de Souza were the recipients of undergraduate fellowships from the Programa Institucional de Bolsas de Iniciação Científica e Apoio à Pesquisa of Hermínio Ometto Foundation.

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  1. Graduate Program in Biomedical Sciences, Centro Universitário da Fundação Hermínio Ometto, FHO, Av. Maximiliano Barutto n° 500, Jardim Universitário, Araras, SP, 13607-339, Brazil

    Cristiane Alves Serra, Alexandre Freire dos Reis, Bruno Calsa, Júlia Venturini Helaehil, Camila Andrea de Oliveira & Maria Esméria Corezola do Amaral

  2. Biomedical College, Centro Universitário da Fundação Hermínio Ometto, FHO, Araras, SP, Brazil

    Cintia Sena Bueno & Suelen Aparecida Ribeiro de Souza

  3. Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil

    Emerielle Cristine Vanzella

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All authors performed all the experiments. B. Calsa and Maria Esméria Corezola do Amaral analyzed the results and revised the manuscript; Maria Esméria Corezola do Amaral designed the study and wrote the manuscript.

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Serra, C.A., dos Reis, A.F., Calsa, B. et al. Quercetin prevents insulin dysfunction in hypertensive animals. J Diabetes Metab Disord 21, 407–417 (2022). https://doi.org/10.1007/s40200-022-00987-4

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