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Postpartum Neuropathies

  • Obstetric Anesthesia (LR Leffert, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review discusses neuropathies intrinsic to the process of labour itself, and those related to obstetric central neuraxial block. The focus is on lower limb pathology. A general approach to the evaluation of patients is provided, emphasising the importance of identifying time-critical conditions.

Recent Findings

Recent work has focussed on the incidence of postpartum neuropathy and confirms how rarely anaesthesia is a causative factor. International guidelines have been developed to minimise the risk of neuraxial-related injury, and to optimise both monitoring of patients with neuraxial block and investigation of abnormal findings.

Summary

Obstetric anaesthetists are frequently asked to see patients with abnormal neurology in the postpartum period. A clear understanding of common pathology and the core tenets of evaluation and management are crucial for safe patient care. While rare, complications related to neuraxial anaesthesia can be devastating, and appropriate preventative measures should be employed to minimise risk.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Chang LY, Carabuena JM, Camann W. Neurologic issues and obstetric anaesthesia. Semin Neurol. 2011;31(4):374–84.

    Article  PubMed  Google Scholar 

  2. Wong CA. Nerve injuries after neuraxial anaesthesia and their medicolegal implications. Best Pract Res Clin Obstet Gynaecol. 2010;24:367–81.

    Article  PubMed  Google Scholar 

  3. McCombe K, Bogod D. Learning from the law A review of 21 years of litigation for nerve injury following central neuraxial blockade in obstetrics. Anaesthesia. 2020;75:541–8.

    Article  CAS  PubMed  Google Scholar 

  4. Boyce H, Plaat F. Post-natal neurological problems. Continuing Education in Anaesthesia, Critical Care & Pain. 2013;13(2):63–6.

    Article  Google Scholar 

  5. O’Flaherty D, McCartney CJL, Ng SC. Nerve injury after peripheral nerve blockade - current understanding and guidelines. BJA Education. 2018;18(12):384–90.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wong CA. Neurologic deficits and labor analgesia. RAPM. 2004;29(4):341–51.

    PubMed  Google Scholar 

  7. Richards A, McLaren T, Paech MJ, Nathan EA, Beattie E, McDonnell N. Immediate postpartum neurological deficits in the lower extremity: a prospective observational study. IJOA. 2017;31:5–12.

    CAS  Google Scholar 

  8. O’Neal M. Lower extremity weakness and numbness in the postpartum period. A case-based review Neurol Clin. 2019;37:103–11.

    PubMed  Google Scholar 

  9. O’Neal MA, Chang LY, Salajegheh MK. Postpartum spinal cord, root, plexus and peripheral nerve injuries involving the lower extremities: a practical approach. Anesth Analg. 2015;120(1):141–8.

    Article  PubMed  Google Scholar 

  10. Howells ACL. Neurological complications in obstetric regional anaesthesia. Anaesthesia and Intensive Care Medicine. 2013;14(8):331–2.

    Article  Google Scholar 

  11. Russell R, Soltanifar S. Neurological complications in obstetric regional anaesthesia. Anaesthesia and Intensive Care Medicine. 2010;11(8):316–8.

    Article  Google Scholar 

  12. Haller G, Pichon I, Gay F-O, Savoldelli G. Risk factors for peripheral nerve injuries following neuraxial labour analgesia: a nested case-control study. Acta Anaesthesiol Scand. 2017;61:1203–14.

    Article  CAS  PubMed  Google Scholar 

  13. Tournier A, Doremieux AC, Drumez E, Labreuche J, Cassim F, Bartolo S, Richart P, Garabedian C, Subtil D. Lower-limb neurologic deficit after vaginal delivery: a prospective observational study. IJOA. 2020;41:35–8.

    CAS  Google Scholar 

  14. Wong CA, Scavone BM, Dugan S, Smith JC, Prather H, Ganchiff JN, McCarthy RJ. Incidence of postpartum lumbosacral spine and lower extremity nerve injuries. Obstetrics and Gynaecology. 2003;101(2):279–88.

    Google Scholar 

  15. Duncan A, Patel S. Neurological complications in obstetric regional anesthetic practice. Journal of Obstetric Anesthesia and Critical Care. 2016;6:3–10.

    Article  Google Scholar 

  16. Chambers DJ, Howells ACL. Neurological complications in obstetric regional anaesthesia. Anaesthesia and Intensive Care Medicine. 2016;17(8):372–4.

    Article  Google Scholar 

  17. Gooding MS, Evangelista V, Pereira L. Carpal tunnel syndrome and meralgia paraesthetica in pregnancy. Obstetrical and Gynaecological Survey. 2020;75(2):121–6.

    Article  Google Scholar 

  18. Chow K, Wong K, Gill A. Severe postpartum femoral neuropathy: a case series. J Obstetr Gynaecol Can. 2021;43(5):603–6.

    Article  Google Scholar 

  19. Rowland C, Kane D, Eogan M. Postpartum femoral neuropathy: managing the next pregnancy. BMJ Case Rep. 2019;12:e232967.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Wang T-T, Sun S, Huang S-Q. Effect of epidural labor analgesia with low concentration of local anesthetics on obstetric outcomes: a systematic review and meta-analysis of randomized controlled trials. Anesth Analg. 2017;124(5):1571–80.

    Article  PubMed  Google Scholar 

  21. Bogod D. Complications after obstetric CNB. In: Royal College of Anaesthetists. 3rd National Audit Project: National Audit of Major Complications of Central Neuraxial Block in the United Kingdom. London: RCoA, 2009. https://www.rcoa.ac.uk/sites/default/files/documents/2019-09/NAP3%20report.pdf (accessed 20/06/2022)

  22. Hong BY, Ko YJ, Kim HW, Lim SH, Cho RY, Lee JI. Intrapartum obturator neuropathy diagnosed after cesarean delivery. Arch Gynecol Obstet. 2010;282:349–50.

    Article  PubMed  Google Scholar 

  23. Kim SH, Kim IH, Lee SY. Sciatic neuropathy after normal vaginal delivery: a case report. J Clin Neurosci. 2020;72:480–2.

    Article  PubMed  Google Scholar 

  24. Pierce C, O’Brien C, O’Herlihy C. Postpartum femoral neuropathy following spontaneous vaginal delivery. Journal of Obstetrics and Gyanecology. 2010;30(2):203–4.

    Article  Google Scholar 

  25. Butchart AG, Mathews M, Surendran A. Complex regional pain syndrome following protracted labour. Anaesthesia. 2012;67:1272–4.

    Article  CAS  PubMed  Google Scholar 

  26. Fernando R, Sultan P, Phillips S. Quick hits in obstetric anesthesia. Cham: Springer; 2022.

  27. Hoefnagel A, Yu A, Kaminski A. Anesthetic complications in pregnancy. Crit Care Clin. 2016;32(1):1–28.

    Article  PubMed  Google Scholar 

  28. Saw J-L, Hale J, Madhavan A, Ringler MD, Toledano M, Naddaf E. Ischiofemoral impingement syndrome provoked by labor: an unusual case of complete sciatic mononeuropathy. Neuroradiol J. 2022;18:19714009221109896.

    Google Scholar 

  29. Hebl JR, Kopp SL, Schroeder DR, Horlocker TT. Neurologic complications after neuraxial anesthesia or analgesia in patients with preexisting peripheral sensorimotor neuropathy or diabetic polyneuropathy. Anesth Analg. 2006;103(5):1294–9.

    Article  PubMed  Google Scholar 

  30. D’Angelo R, Smiley RM, Riley ET, Segal S. Serious complications related to obstetric anesthesia The Serious Complication Repository Project of the Society for Obstetric Anesthesia and Perinatology. Anesthesiology. 2014;120(6):1505–12.

    Article  PubMed  Google Scholar 

  31. Cook TM, Counsell D, Wildsmith JAW. Royal College of Anaesthetsits Third National Audit Project Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. Br J Anaesth. 2009;102:179–90.

    Article  CAS  PubMed  Google Scholar 

  32. Ruppen W, Derry S, McQuay H, Moore A. Incidence of epidural haematoma, infection, and neurologic injury in obstetric patients with epidural analgesia/ anesthesia. Anesthesiology. 2006;105:394–9.

    Article  PubMed  Google Scholar 

  33. Plaat F, Lucas DN, Hartopp R, Knight M. Neurological complications following obstetric regional anaesthesia: a four year study of epidural haematoma and abscess. IJOA. 2019;39:S8.

    Google Scholar 

  34. •• Yentis SM, Lucas DN, Brigante L, Collis R, Cowley P, Denning S, Fawcett WJ, Gibson A, Safety guideline: neurological monitoring associated with obstetric neuraxial block. A joint guideline by the Association of Anaesthetists and the Obstetric Anaesthetists’ Association. Anaesthesia. 2020;2020(75):913–9. (This guideline provides recommendations on monitoring the recovery of obstetric patients with neuraxial block, and escalation of concerns in a way that is practicable and easy to implement in a busy obstetric unit.)

    Article  Google Scholar 

  35. Loo CC, Dahlgren G, Irestedt L. Neurological complications in obstetric regional anaesthesia. IJOA. 2000;9:99–124.

    CAS  Google Scholar 

  36. Neal JM, Barrington MJ, Brull R, Hadzic A, Hebl JR, Horlocker TT, Huntoon MA, Kopp SL, Rathmell JP, Watson JC. The second ASRA practice advisory on neurologic complications associated with regional anesthesia and pain medicine Executive Summary 2015. Regional Anesthesia and Pain Medicine. 2015;40(5):401–30.

    Article  CAS  PubMed  Google Scholar 

  37. Broadbent CR, Maxwell WB, Ferrie R, Wilson DJ, Gawne-Cain M, Russell R. Ability of anaesthetists to identify a marked lumbar interspace. Anaesthesia. 2000;55:1122–6.

    Article  CAS  PubMed  Google Scholar 

  38. Margarido CB, Mikhael R, Arzola C, Balki M, Carvalho JCA. The intercristal line determined by palpation is not a reliable anatomical landmark for neuraxial anesthesia. Can J Anesth. 2011;58:262–6.

    Article  PubMed  Google Scholar 

  39. Reynolds F. Logic in the safe practice of spinal anaesthesia. Anaesthesia. 2000;55(11):1045–6.

    Article  CAS  PubMed  Google Scholar 

  40. Bogod D. Keeping in the Reynolds zone. IJOA. 2014;23:201–3.

    Google Scholar 

  41. Hewson DW, Bedforth NM, Hardman JG. Spinal cord injury arising in anaesthesia practice. Anaesthesia. 2018;73(Suppl. 1):43–50.

    Article  PubMed  Google Scholar 

  42. Young B, Onwochei D, Desai N. Conventional landmark palpation vs preprocedural ultrasound for neuraxial analgesia and anaesthesia in obstetrics – a systematic review and meta-analysis with trial sequential analyses. Anaesthesia. 2021;76:818–31.

    Article  CAS  PubMed  Google Scholar 

  43. Moen V, Dahlgren N, Irestedt L. Severe neurological complications after central neuraxial blockades in Sweden 1990–1999. Anesthesiology. 2004;101:950–9.

    Article  CAS  PubMed  Google Scholar 

  44. Rosero EB, Joshi GP. Nationwide incidence of serious complications of epidural analgesia in the United States. Acta Anaesthesiol Scand. 2016;60:810–20.

    Article  CAS  PubMed  Google Scholar 

  45. Bos EME, Haumann J, de Quelerij M, Vandertop WP, Kalkman CJ, Hollman MW, Lirk P. Haematoma and abscess after neuraxial anaesthesia: a review of 647 cases. BJA. 2018;120(4):693–704.

    Article  CAS  PubMed  Google Scholar 

  46. Moen V, Irestedt L. Neurological complications following central neuraxial blockades in obstetrics. Curr Opin Anaesthesiol. 2008;21:275–80.

    Article  PubMed  Google Scholar 

  47. Reynolds F. Infection as a complication of neuraxial blockade. IJOA. 2005;14:183–8.

    Google Scholar 

  48. Lagerkranser M, Lindquist C. Neuraxial blocks and spinal haematoma: review of 166 cases published 1994–2015 Part 2: diagnosis, treatment, and outcome. Scandinavian Journal of Pain. 2017;15:130–6.

    Article  PubMed  Google Scholar 

  49. •• Bauer ME, et al. The Society for Obstetric Anesthesia and Perinatology Interdisciplinary consensus statement of neuraxial procedures in obstetric patients with thrombocytopenia. Anesth Analg. 2021;132(6):1531–44. (Up-to-date, evidence-based guidelines on managing the obstetric patient with thrombocytopenia, which highlight the importance of considering the risk of alternatives to neuraxial block and involving the patient in the decision-making process.)

    Article  PubMed  Google Scholar 

  50. Association of Anaesthetists of Great Britain and Ireland, Obstetric Anaesthetists’ Association and Regional Anaesthesia UK. Regional anaesthesia and patients with abnormalities of coagulation. Anaesthesia 2013:68:966–72

  51. Knight M, Bunch K, Tuffnell D, Patel R, Shakespeare J, Kotnis R, Kenyon S, Kurinczuk JJ (Eds.) on behalf of MBRRACE-UK. Saving lives, improving mothers’ care - lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries in Maternal Deaths and Morbidity 2017–19. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2021.

  52. •• Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R. The Society for Obstetric Anesthesia and Perinatology consensus statement on the anesthetic management of pregnant and postpartum women receiving thromboprophylaxis or higher dose anticoagulants. Anesthesia & Analgesia. 2018;126(3):928–44. (Guidance on safe time intervals for neuraxial block insertion after anti-coagulation adminstration, specific to the obstetric patient. Decision models for the clinician faced with difficult risk-benefit discussions with patients.••)

    Article  Google Scholar 

  53. Roderick E, Hoyle J, Yentis SM. A national survey of neurological monitoring practice after obstetric regional anaesthesia in the UK. Anaesthesia. 2017;72:755–9.

    Article  CAS  PubMed  Google Scholar 

  54. Grewal S, Hocking G, Wildsmith JAW. Epidural abscesses. BJA. 2006;96(3):292–302.

    Article  CAS  PubMed  Google Scholar 

  55. American Society of Anesthesiologists Task Force on infectious complications associated with neuraxial techniques. Practice advisory for the prevention, diagnosis, and management of infectious complications associated with neuraxial techniques. Anesthesiology. 2010;112:530–45.

    Article  Google Scholar 

  56. Rice I, Wee MYK, Thomson K. Obstetric epidurals and chronic adhesive arachnoiditis. BJA. 2004;92(1):109–20.

    Article  CAS  PubMed  Google Scholar 

  57. Association of Anaesthetists of Great Britain and Ireland. Safety guideline: skin antisepsis for central neuraxial blockade. Anaesthesia. 2014;69:1279–86.

    Article  Google Scholar 

  58. Palanisamy A, Kinsella SM. Spinal tranexamic acid - a new killer in town. Anaesthesia. 2019;74:831–3.

    Article  CAS  PubMed  Google Scholar 

  59. Patel S, Robertson B, McConachie I. Catastrophic drug errors involving tranexamic acid administered during spinal anaesthesia. Anaesthesia. 2019;74:909–14.

    Article  Google Scholar 

  60. Ahren DP, Gibbons D, Dodds M, Timlin M, Cassidy N, Morris S, Synnott K, Butler JS. Operative management of perinatal lumbar disc herniation and cauda equina syndrome: A case series. Ir J Med Sci. 2018;187(Suppl 10):S324.

    Google Scholar 

  61. Bryant C, Wharton N, Alexander R. Psychogenic paresis following neuraxial anaesthesia in a complex obstetric case. IJOA. 2015;24(2):200–1.

    CAS  Google Scholar 

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Correspondence to Roshan Fernando.

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Sinnott, M., Fernando, R. Postpartum Neuropathies. Curr Anesthesiol Rep 13, 49–58 (2023). https://doi.org/10.1007/s40140-023-00550-8

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