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Green Synthesis of Zinc Oxide Nanoparticles (ZnO NPs) Using Cissus quadrangularis: Characterization, Antimicrobial and Anticancer Studies

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

In the present study, zinc oxide nanoparticles (ZnO NPs) were synthesized using the stem aqueous extracts of Cissus quadrangularis (Cq) and characterized using UV, FTIR, XRD, TEM, SAED and EDAX. The synthesized Cq-ZnO NPs showed its optical absorbance at 378 nm and observed as spherical particles with a size of about ~ 75 to 90 nm. The potential antibacterial activity of Cq-ZnO NPs showed an effective inhibition of M. smegmatis at 50 µg/ml when compared to other bacterial species. The antiproliferative effect was observed at 100 μg/ml on MIA PaCa-2 cell lines with IC50 value of 7.02 ± 0.02 µg/ml at 24 h. The synthesized Cq-ZnO NPs was found potential activity against bacterial pathogens and cancer cells. Therefore, they may possibly be employed as useful antibacterial and antiproliferative agents.

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Acknowledgements

The authors gratefully acknowledge Mr. Anirudha Karati, Central Electron Microscopy Facility, Department of Chemistry, Indian Institute of Technology-Madras for HR-TEM analysis. Dr. Shanthi Sathappan thank the University Grants Commission for the award of Dr. D.S. Kothari Postdoctoral Fellowship (No. F.4-2/2006 (BSR)/BL/16-17/0311).

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Authors and Affiliations

  1. Department of Zoology, University of Madras, Guindy Campus, Chennai, 600025, India

    Shanthi Sathappan, Nithya Kirubakaran & Janarthanan Sundaram

  2. Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology - Madras, Chennai, 600036, India

    Dharanivasan Gunasekaran, Piyush Kumar Gupta & Rama Shanker Verma

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  1. Shanthi Sathappan
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  2. Nithya Kirubakaran
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  3. Dharanivasan Gunasekaran
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  6. Janarthanan Sundaram
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Correspondence to Janarthanan Sundaram.

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Significance statement The aim of the present study is to synthesize nanoparticles of zinc from aqueous stem extract of Cissus quadrangularis (Cq-ZnO NPs) and to examine its antibacterial activity against Gram-positive and Gram-negative bacteria and also its anticancer activity on pancreatic adenocarcinoma cells.

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Sathappan, S., Kirubakaran, N., Gunasekaran, D. et al. Green Synthesis of Zinc Oxide Nanoparticles (ZnO NPs) Using Cissus quadrangularis: Characterization, Antimicrobial and Anticancer Studies. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 91, 289–296 (2021). https://doi.org/10.1007/s40011-020-01215-w

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