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Synthesis and Antibacterial Activity of Novel N-Methyl Pyrrolidine Dendrimers via [3+2] Cycloaddition

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Abstract

One-pot synthesis of novel N-methyl pyrrolidine dendrimers has been accomplished in good yield via a facile [3+2] cycloaddition of azomethine ylide with chalcone moiety of the dendrimer as a dipolarophile. All the pyrrolidine dendrimers exhibited moderate and comparable antibacterial activity as that of the standard viz., chloramphenicol against Bacillus subtilis, E. coli, Klebsiella pneumoniae and species of Streptococcus by agar well diffusion method.

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Acknowledgments

The authors thank CSIR, New Delhi, for financial assistance and DST-FIST for providing NMR facilities to the department and also grateful to the department of biotechnology, Vels University, Chennai, India. For anti bacterial studies. AT thanks CSIR-UGC for fellowship in the form of SRF.

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Madras, Maraimalai Campus, Guindy, Chennai, 600 025, India

    Perumal Rajakumar, Ayyavu Thirunarayanan & Sebastian Raja

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  1. Perumal Rajakumar
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  2. Ayyavu Thirunarayanan
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  3. Sebastian Raja
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Correspondence to Perumal Rajakumar.

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Rajakumar, P., Thirunarayanan, A. & Raja, S. Synthesis and Antibacterial Activity of Novel N-Methyl Pyrrolidine Dendrimers via [3+2] Cycloaddition. Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci. 84, 371–379 (2014). https://doi.org/10.1007/s40010-013-0120-6

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  • DOI: https://doi.org/10.1007/s40010-013-0120-6

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