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Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration

  • Review Article
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Background:

Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue engineering (ATE) provides a promising way to solve this problem.

Methods:

This review summarizes the current ATE strategies for soft tissue reconstruction, and introduces potential construction methods for ATE.

Results:

Scaffold-based and scaffold-free strategies are the two main approaches in ATE. Although several of these methods have been effective clinically, both scaffold-based and scaffold-free strategies have limitations. The third strategy is a synergistic tissue engineering strategy and combines the advantages of scaffold-based and scaffold-free strategies.

Conclusion:

Personalized construction, stable survival of reconstructed tissues and functional recovery of organs are future goals of building tissue-engineered fat for ATE.

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Data availability

The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

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Acknowledgements

This work was supported by the National Nature Science Foundation of China (82072197, 82072197, 82072196, 82072196).

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Authors and Affiliations

  1. Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, China

    Jing Zhao, Feng Lu & Ziqing Dong

  2. Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515063, Guangdong, China

    Jing Zhao

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  1. Jing Zhao
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  2. Feng Lu
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JZ: drafting the article; substantial contribution to the conception and design of the study, or acquisition, interpretation and analysis of data. FL: revising the article critically for the important intellectual content. ZD: final approval of the version to be published.

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Correspondence to Feng Lu or Ziqing Dong.

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Zhao, J., Lu, F. & Dong, Z. Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration. Tissue Eng Regen Med 21, 395–408 (2024). https://doi.org/10.1007/s13770-023-00607-z

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  • DOI: https://doi.org/10.1007/s13770-023-00607-z

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