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Alteration in the expression of long non-coding RNAs in the circulation of migraineurs

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Abstract

Background

Current studies have shown emerging roles of lncRNAs in the pathobiology of neuropathic pain and migraine.

Methods

We have chosen five lncRNAs, namely, PVT1, DSCAM-AS, MEG3, LINC-ROR, and SPRY4-IT1 for assessment of their expression in the circulation of migraineurs.

Results

Expressions of PVT1 and MEG3 were higher in total migraineurs and both subgroups compared with controls (P < 0.0001). Meanwhile, expression of both lncRNA was higher in migraineurs with aura versus migraineurs without aura (P value < 0.0001 and = 0.01, respectively). Expression of DSCAM-AS1 was not different between any groups of patients compared with controls. Expression of LINC-ROR was elevated in total patients and patients with aura compared with controls (P value = 0.0002 and < 0.0001, respectively). It was also over-expressed in migraineurs with aura vs. migraineurs without aura (P = 0.01). Finally, expression of SPRY4-IT1 was higher in total patients and patients without aura compared with migraine-free persons (P values < 0.0001). Expressions of five mentioned lncRNAs were correlated in almost all study groups. In patients without aura, correlations were significant only for two pairs (SPRY4-IT1/PVT1 and SPRY4-IT1/DSCAM-AS1). PVT1 and MEG3 had the appropriate AUC, sensitivity and specificity values for separation of total migraineurs and both groups of patients from controls. The highest AUC value was reported for PVT1 in separation of migraineurs with aura from healthy controls (AUC = 0.98).

Conclusion

Cumulatively, our study shows evidence for deregulation of lncRNAs in migraineurs.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Acknowledgements

This study was financially supported by Shahid Beheshti University of Medical Sciences.

Funding

Not applicable.

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Authors and Affiliations

  1. Institute of Human Genetics, Jena University Hospital, Jena, Germany

    Mohammad Taheri

  2. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

  3. Institute of Molecular Medicine Finland (FIMM), HiLIFE University of Helsinki, Helsinki, Finland

    Reyhaneh Eghtedarian

  4. Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

    Solat Eslami

  5. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Solat Eslami

  6. Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

    Bashdar Mahmud Hussen

  7. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  8. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Seyed Abdulmajid Ayatollahi

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  1. Mohammad Taheri
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  2. Reyhaneh Eghtedarian
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  6. Seyed Abdulmajid Ayatollahi
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Contributions

SGF wrote the paper and revised it. MT and SAA designed the study. BMH and RE collected the data and conducted the experiments. SE analyzed the data. All authors approved the submitted manuscript.

Corresponding authors

Correspondence to Soudeh Ghafouri-Fard or Seyed Abdulmajid Ayatollahi.

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The authors declare they have no conflict of interest.

Ethical approval and consent to participate

All procedures were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent forms were obtained from all study participants. The study protocol was approved by the ethical committee of Shahid Beheshti University of Medical Sciences (IR.SBMU.MSP.REC.1400.563).

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Taheri, M., Eghtedarian, R., Eslami, S. et al. Alteration in the expression of long non-coding RNAs in the circulation of migraineurs. Acta Neurol Belg (2024). https://doi.org/10.1007/s13760-024-02513-0

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  • DOI: https://doi.org/10.1007/s13760-024-02513-0

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