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ZnO as a promising nanocarrier for efficient delivery of 5-fluorouracil anticancer drug

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Abstract

5-fluorouracil (5-Fu) is a chemotherapy drug commonly used in various types of cancers, including lung cancer. However, in order to decrease its side effects, the drug had to be loaded onto a nanocarrier. In this work, ZnO nanoparticles are prepared via sedimentation of Zn(OAc)2·2H2O in absolute ethanol and specified by some analytical techniques. Then, 5-fluorouracil molecules are loaded onto the surface of nanomaterial and loading/ release properties of the mentioned drug are investigated under in vitro conditions. After that, the electronic sensitivity and effectiveness of ZnO nanocluster bearing 5-fluorouracil were investigated theoretically with the B3LYP/wB97XD density functional theory (DFT). Theoretical parameters including band gap energy (Eg), molecular electrostatic potential (MEP), adsorption energy (Ead), density of electronic states, and global hardness (η) are also analyzed and compared. Furthermore, an MTT experiment was planned to investigate cytocompatibility of the drug-loaded material on the lung cancer cells A549. This study confirmed that drug-loaded material has a higher antiproliferative activity compared to free drug against A549 cancer cells.

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References

  1. Y.F. Mustafa, N.A. Mohammed, A promising oral 5-Fluorouracil prodrug for lung tumor: Synthesis, characterization, and release. Biochem. Cell. Arch. 21, (2021)

  2. P.H. Sugarbaker, After thirty years of experience with early postoperative intraperitoneal 5-fluorouracil now saying goodbye. Surg. Oncol. 42, 101757 (2022)

    Article  PubMed  Google Scholar 

  3. Y. Qin, J. Xie, H. Wang, Efficacy and safety of combined use of docetaxelgemcitabine chemotherapy and 5-fluorouracil targeted therapy in the treatment of advanced non-small cell lung cancer. Trop. J. Pharm. Res. 21(7), 1523–1529 (2022)

    Article  CAS  Google Scholar 

  4. A.A. Valencia-Lazcano, D. Hassan, M. Pourmadadi, R. Behzadmehr, A. Rahdar, D.I. Medina, A.M. Díez-Pascual, 5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy. Eur. J. Med. Chem. 246, 114995 (2023)

    Article  CAS  PubMed  Google Scholar 

  5. T.T. Dongsar, T.S. Dongsar, N. Gupta, W.H. Almalki, A. Sahebkar, P. Kesharwani, Emerging potential of 5-Fluorouracil-loaded chitosan nanoparticles in cancer therapy. J. Drug Deliv. Sci. Technol. 104371 (2023)

  6. Y. Zhihong, Y. Ye, A. Pejhan, A.H. Nasr, N. Nourbakhsh, R. Tayebee, A theoretical study on the pure and doped ZnO nanoclusters as effective nanobiosensors for 5-fluorouracil anticancer drug adsorption. Appl. Organomet. Chem. 34(4), e5534 (2020)

    Article  CAS  Google Scholar 

  7. E. Shakerzadeh, K.K. Zborowski, E.C. Anota, M.T. Nguyen, Pristine and alkali and alkaline Earth metals encapsulated B36N36 nanoclusters as prospective delivery agents and detectors for 5-fluorouracil anticancer drug. Appl. Organomet. Chem. 36(7), e6721 (2022)

    Article  CAS  Google Scholar 

  8. S.A. Thomas, Z. Grami, S. Mehta, K. Patel, Adverse effects of 5-fluorouracil: focus on rare side effects. Cancer Cell Microenviron. 3(2), e1266 (2016)

    Google Scholar 

  9. K. Suwannakot, N. Sritawan, R. Prajit, A. Aranarochana, A. Sirichoat, W. Pannangrong, P. Wigmore, J.U. Welbat, Melatonin protects against the side-effects of 5-fluorouracil on hippocampal neurogenesis and ameliorates antioxidant activity in an adult rat hippocampus and prefrontal cortex. Antioxidants. 10(4), 615 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. G. Naren, J. Guo, Q. Bai, N. Fan, B. Nashun, Reproductive and developmental toxicities of 5-fluorouracil in model organisms and humans. Expert Rev. Mol. Med. 24, e9 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. S.M. Asil, J. Ahlawat, G.G. Barroso, M. Narayan, Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases. Biomater. Sci. 8(15), 4109–4128 (2020)

    Article  PubMed Central  Google Scholar 

  12. X. Zheng, P. Zhang, Z. Fu, S. Meng, L. Dai, H. Yang, Applications of nanomaterials in tissue engineering. RSC Adv. 11(31), 19041–19058 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. T.A. Singh, J. Das, P.C. Sil, Zinc oxide nanoparticles: A comprehensive review on its synthesis, anticancer and drug delivery applications as well as health risks. Adv. Coll. Interface. Sci. 286, 102317 (2020)

    Article  CAS  Google Scholar 

  14. S. Anjum, M. Hashim, S.A. Malik, M. Khan, J.M. Lorenzo, B.H. Abbasi, C. Hano, Recent advances in zinc oxide nanoparticles (ZnO NPs) for cancer diagnosis, target drug delivery, and treatment. Cancers 13(18), 4570 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. V. Puspasari, A. Ridhova, A. Hermawan, M.I. Amal, M.M. Khan, ZnO-based antimicrobial coatings for biomedical applications. Bioprocess Biosyst. Eng. 45(9), 1421–1445 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. P. Sathishkumar, Z. Li, R. Govindan, R. Jayakumar, C. Wang, F.L. Gu, Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: molecular-level interaction studies. Appl. Surf. Sci. 536, 147741 (2021)

    Article  CAS  Google Scholar 

  17. A. Dakhlaoui, M. Jendoubi, L.S. Smiri, A. Kanaev, N. Jouini, Synthesis, characterization and optical properties of ZnO nanoparticles with controlled size and morphology. J. Cryst. Growth 311(16), 3989–3996 (2009)

    Article  CAS  Google Scholar 

  18. Z. Liu, Z. Yu, L. Zhang, R. Tayebee, S. Pourmojahed, E.E. Shahri, X. Chen, Studying loading of 5-fluorouracil onto the surface of gold–silver nanocomposite utilizing DLS and UV–Vis spectroscopy. Chem. Papers 1–11 (2023)

  19. R. Tayebee, F. Javadi, G. Argi, Easy single-step preparation of ZnO nano-particles by sedimentation method and studying their catalytic performance in the synthesis of 2-aminothiophenes via Gewald reaction. J. Mol. Catal. A Chem. 368, 16–23 (2013)

    Article  Google Scholar 

  20. G. Acharya, K. Park, Mechanisms of controlled drug release from drug-eluting stents. Adv. Drug Deliv. Rev. 58(3), 387–401 (2006)

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Oncology Department, Kunming Children’s Hospital, Kunming, 650000, China

    Ye Li & Jianjun Zhu

  2. Department of Neurosurgery, First People’s Hospital of Kunming, Kunming, 650000, China

    Nan Zhao & Bohu Liu

  3. Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA

    Gang Ma

  4. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China

    Jiajun Xu

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  1. Ye Li
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  2. Jianjun Zhu
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  3. Nan Zhao
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  4. Gang Ma
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  5. Bohu Liu
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Correspondence to Jiajun Xu.

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Li, Y., Zhu, J., Zhao, N. et al. ZnO as a promising nanocarrier for efficient delivery of 5-fluorouracil anticancer drug. J IRAN CHEM SOC 20, 2871–2877 (2023). https://doi.org/10.1007/s13738-023-02883-x

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  • DOI: https://doi.org/10.1007/s13738-023-02883-x

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