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Perlite–SO3H nanoparticles: very efficient and reusable catalyst for three-component synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amine derivatives under ultrasound irradiation

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Abstract

An efficient green approach for the synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amine derivatives, via a three-component one-pot condensation reaction of o-phenylenediamine, aromatic aldehydes and cyclohexyl isocyanide in the presence of perlite–SO3H nanoparticles (diameter/thickness of platelets < 100 nm) under ultrasound irradiation has been demonstrated. The present method offers advantages such as shorter reaction time, easy work-up, excellent yields, recovery and reusability of catalyst. In addition, the methodology has been prosperous in getting the green chemistry purposes such as natural catalyst, using ultrasound irradiation instead of conventional heating and stirring, and a non-hazardous products in the thus combining the features of both economic and environmental advantages.

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Acknowledgements

The authors thank Science and Research Branch, Islamic Azad University for the support and guidance.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Morteza Rouhani

  2. Department of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran

    Ali Ramazani

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  1. Morteza Rouhani
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Correspondence to Morteza Rouhani.

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Rouhani, M., Ramazani, A. Perlite–SO3H nanoparticles: very efficient and reusable catalyst for three-component synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amine derivatives under ultrasound irradiation. J IRAN CHEM SOC 15, 2375–2382 (2018). https://doi.org/10.1007/s13738-018-1426-8

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  • DOI: https://doi.org/10.1007/s13738-018-1426-8

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