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A one-pot four-component reaction providing quinoline-based 1,4-dihydropyridines

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Abstract

In this work, highly functionalized novel quinolinyl 1,4-dihydropyridines were synthesized in a facile and efficient method. A variety of quinoline-based dihydropyridines were obtained via a one-pot four-component condensation of 2-chloroquinoline-3-carbaldehydes, arylamines, acetylenedicarboxylates and malononitrile or ethyl cyanoacetate in moderate to excellent yields. The atom-efficiency, high-yielding, mild reaction conditions, use of simple experimental procedure and prompt isolation of the products are the main advantages of these reactions.

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Fig. 1
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The authors acknowledge the University of Tehran for financial support of this research.

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  1. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155 6455, Tehran, Iran

    Mehdi Ghandi & Nahid Zarezadeh

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Ghandi, M., Zarezadeh, N. A one-pot four-component reaction providing quinoline-based 1,4-dihydropyridines. J IRAN CHEM SOC 12, 1313–1324 (2015). https://doi.org/10.1007/s13738-015-0596-x

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