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Pathological mechanisms of cold and mechanical stress in modulating cancer progression

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Abstract

Environmental temperature and cellular mechanical force are the inherent factors that participate in various biological processes and regulate cancer progress, which have been hot topics worldwide. They occupy a dominant part in the cancer tissues through different approaches. However, extensive investigation regarding pathological mechanisms in the carcinogenic field. After research, we found cold stress via two means to manipulate tumors: neuroscience and mechanically sensitive ion channels (MICHs) such as TRP families to regulate the physiological and pathological activities. Excessive cold stimulation mediated neuroscience acting on every cancer stage through the hypothalamus-pituitary-adrenocorticoid (HPA) to reach the target organs. Comparatively speaking, mechanical force via Piezo of MICHs controls cancer development. The progression of cancer depends on the internal activation of proto-oncogenes and the external tumorigenic factors; the above two means eventually lead to genetic disorders at the molecular level. This review summarizes the interaction of bidirectional communication between them and the tumor. It covers the main processes from cytoplasm to nucleus related to metastasis cascade and tumor immune escape.

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Availability of data and materials

The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by grants from the National Nature Science Foundation of China (82072985), Heilongjiang Province Innovation Base Award Project (JD2023SJ03), Wu-Jieping Medical Foundation (320.6750.19089-22,320.6750.19089-48), Beijing Medical Award Foundation (YXJL-2019-1416-0069), Hai Yan Youth Fund of Harbin Medical University Cancer Hospital (JJQN2021-02), the Fundamental Research Funds for the Provincial Universities (2021-KYYWF-0253), Natural Science Foundation of Heilongjiang Province (LH2022H065), Scientific research project of the Heilongjiang Provincial Health Commission (20210808020126).

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  1. Yunjing Hou, Xinxin Yang, and Lin He contributed equally to this study.

Authors and Affiliations

  1. Harbin Medical University, Harbin, China

    Yun-jing Hou, Xin-xin Yang & Hong-xue Meng

  2. Department of Pathology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, China

    Hong-xue Meng

  3. Department of Precision Medicine Center, Harbin Medical University Cancer Hospital, Harbin, China

    Yun-jing Hou & Xin-xin Yang

  4. Department of Stomatology, Heilongjiang Provincial Hospital, Harbin, China

    Lin He

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Yun-jing Hou, Xin-xin Yang, Lin He, and Hong-xue Meng. Yun-jing Hou, Xin-xin Yang reviewed the literature and wrote the first draft. Lin He contributed to the conception and design of the manuscript. Hong-xue Meng administrated and finalized the manuscript. All authors read and approved the final version of the manuscript. Data authentication is not applicable.

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Hou, Yj., Yang, Xx., He, L. et al. Pathological mechanisms of cold and mechanical stress in modulating cancer progression. Human Cell 37, 593–606 (2024). https://doi.org/10.1007/s13577-024-01049-y

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