Abstract
Objective
Although the organic compounds, 2-propylaniline and 4-propylaniline are frequently used in many industrial sectors, and have little information about the potential genetic toxicity, and it is covered by the Occupational Safety & Health Act (OSHAct) in Korea.
Methods
The mutation test of 2-propylaniline and 4-propylaniline was evaluated in five different doses for each chemical through a well-known Ames bacterial mutation test. This test was performed regardless of metabolic activation.
Results
In this assay, we obtained positive results under all tested conditions, indicating that these two chemicals have mutagenic and potentially carcinogenic properties.
Conclusion
Both 2-propylaniline and 4-propylaniline were mutagenic under the conditions of these tests. This result means that all of these chemicals exhibit mutations and potential carcinogenicity.
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Rim, KT., Kim, SJ. Mutagenicities of 2-Propylaniline and 4-Propylaniline Determined by a Bacterial Reverse Mutation (Ames) Assay. Toxicol. Environ. Health Sci. 10, 59–64 (2018). https://doi.org/10.1007/s13530-018-0347-3
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DOI: https://doi.org/10.1007/s13530-018-0347-3