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Phyto-synthesis, characterization of magnesium oxide nanoparticles using aqueous extract of Piper betle leaf and an assessment of its antioxidant potential

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Abstract

Bio-nanotechnology is a fusion of nanotechnology with biological technology. Biological methods are used to synthesize the nanomaterials through the concept of bio-nanotechnology. The novelty of the present investigation is to synthesize the magnesium oxide nanoparticles (MgO NPs) with enhanced antioxidant efficiency using P. betle leaf extract. In this study, Piper betle leaf extract was employed as a bio-reducing agent to synthesize the MgO NPs. The physicochemical characteristics of MgO NPs were investigated using UV–visible spectroscopy, XRD, FT-IR, SEM, and TGA. The optical properties of MgO NPs were confirmed by the UV–visible spectra having a wide absorption peak at 384 nm with a band gap energy of 3.2 eV. FT-IR spectrum showed peaks at 486 cm−1 and 699 cm−1, which correlate with the metal oxide functional groups. XRD spectra determined the formation of crystalline MgO NPs with a size of 18–20 nm. SEM analysis revealed that the synthesized nanoparticles were spherical. Thermogravimetric analysis proved that 33.6% of weight loss was due to removing water molecules, carbon, and organic compounds on P. betle-mediated MgO NPs. DPPH analysis was used to measure the antioxidant activity of MgO NPs produced. MgO NPs had an IC50 value of 143.71 µg/mL. At a 500 µg/ml concentration, the DPPH assay of P. betle-mediated MgO NPs could achieve 88%. The results showed that the P. betle-mediated MgO NPs possess strong antioxidant capabilities and could be plausibly used for drug design and development.

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Authors and Affiliations

  1. Department of Biotechnology, PSG College of Arts & Science, Coimbatore, 641 014, Tamilnadu, India

    Rajiv Periakaruppan

  2. Department of Biochemistry, Biotechnology & Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641 043, Tamilnadu, India

    Monica Jannett S.

  3. Department of Biotechnology, Sri Ramakrishna College of Arts & Science, Coimbatore, Tamilnadu, India

    P. Vanathi

  4. Centre for Interfaces & Nanomaterials, Department of Biotechnology, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, 600 062, India

    Selva Kumar T.

  5. Vegetable Research Station, Tamil Nadu Agricultural University, Palur, 607 102, Cuddalore, India

    Karungan Selvaraj Vijai Selvaraj

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  3. P. Vanathi
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  4. Selva Kumar T.
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PR: supervision, funding acquisition, and project administration.

MJS: investigation, methodology, writing – original draft preparation.

PV: data curation and writing.

SKT: data curation and writing.

KSVS: data curation and writing.

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Correspondence to Rajiv Periakaruppan or Karungan Selvaraj Vijai Selvaraj.

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Periakaruppan, R., S., M.J., Vanathi, P. et al. Phyto-synthesis, characterization of magnesium oxide nanoparticles using aqueous extract of Piper betle leaf and an assessment of its antioxidant potential. Biomass Conv. Bioref. (2023). https://doi.org/10.1007/s13399-023-05116-6

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