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Improvised strategy of ethanolic nanovesicular gel of phospholipon 90G for transdermal delivery of luliconazole to mitigate fungal diseases

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Abstract

The research work involves the development and characterization of ethanolic nanovesicular gel of different concentrations of the specified chemicals so as to estimate the optimized one among the rest. For the determination of its stability and suitability, optimized formulation was carried to a number of evaluation parameters such as particle size, zeta potential, polydispersity index (PDI), % entrapment efficiency (%EE), attenuated total internal reflection Fourier transforms infra-red spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), atomic force microscopy (AFM), in vitro drug permeation study, stability studies, viscosity, pH, spreadability, extrudability, and last but not least, anti-fungal activity done by considering tube dilution assay. And finally, the results obtained were recorded and analyzed for all the parameters. The outcomes revealed that among nine nanovesicular formulations, ENV5 was found to be optimized, as because of its appropriate results for particle size, PDI, and zeta potential and highest % entrapment efficiency of about 169.5 nm, 0.407, −37.9 mV, and 80.07 ± 0.55% respectively, whereas in vitro drug permeation study expresses % cumulative release of 78.59 ± 0.43 in about 24 h. The suspension of nanovesicular system and lyophilized form of nanovesicular suspension both were examined and found to be very much stable at 4°C/60 ± 5 % RH than that of 25 °C/60 ± 5 % RH. Ultimately, the outcomes of the evaluation parameters have proved that the buildup is stable and suitable for topical application hence, leading to efficacious therapy of fungal diseases.

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Authors and Affiliations

  1. Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, India

    Vivek Dave

  2. Department of Pharmacy, Banasthali Vidyapith, Jaipur, Rajasthan, India

    Nikita Gupta

  3. Department of Bio-science and Biotechnology, Banasthali Vidyapith, Jaipur, Rajasthan, India

    Anand Prakesh

  4. Department of Home Science, Mahila Maha Vidyalaya, Banaras Hindu University, Varanasi, India

    Prashansa Sharma

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  1. Vivek Dave
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  2. Nikita Gupta
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  4. Prashansa Sharma
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Correspondence to Prashansa Sharma.

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Dave, V., Gupta, N., Prakesh, A. et al. Improvised strategy of ethanolic nanovesicular gel of phospholipon 90G for transdermal delivery of luliconazole to mitigate fungal diseases. Biomass Conv. Bioref. 13, 15463–15469 (2023). https://doi.org/10.1007/s13399-021-02039-y

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  • DOI: https://doi.org/10.1007/s13399-021-02039-y

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