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The association between glycemic control and lung function impairment in individuals with diabetes: the Saku study

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Abstract

Aim

Though diabetes is a risk factor for lung function impairment, whether the glycemic control level affects lung function in individuals with diabetes remains unclear. The present study aimed to assess the association between glycemic control level and restrictive or obstructive lung function impairment in individuals with diabetes.

Methods

This cross-sectional study included 1028 individuals with diabetes, aged 40–69 years, who underwent a medical checkup between April 2008 and March 2014. Hemoglobin A1c (HbA1c) was categorized as  < 6.9%, 7.0–7.9%, and  ≥ 8.0%. Restrictive and obstructive lung function impairment was defined by a forced vital capacity (FVC) < 80% predicted and a forced expiratory volume in 1 s to FVC ratio < 0.70.

Results

Of the participants, 8.7% and 6.3% were classified as having restrictive and obstructive lung function impairment, respectively. The multivariable-adjusted odds ratios and 95% confidence intervals for restrictive lung function impairment were 1.43 (0.84–2.42) in individuals with HbA1c 7.0–7.9%, and 2.42 (1.38–4.26) in individuals with HbA1c ≥ 8.0%, compared with those who had HbA1c < 6.9% (p for trend = 0.002). In contrast, glycemic control level was not associated with obstructive lung function impairment (p for trend = 0.749).

Conclusions

Poor glycemic control was associated with restrictive lung function impairment in individuals with diabetes. Good glycemic control would be important to minimize restrictive lung function impairment in individuals with diabetes.

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References

  1. Yokomichi H, Nagai A, Hirata M, Kiyohara Y, Muto K, Ninomiya T, BioBank Japan Cooperative Hospital Group, Yamagata Z, et al. Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort. J Epidemiol. 2017;27:S98–106.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Van den Borst B, Gosker HR, Zeegers MP, Schols AM. Pulmonary function in diabetes: a metaanalysis. Chest. 2010;138:393–406.

    Article  PubMed  Google Scholar 

  3. Sonoda N, Morimoto A, Tatsumi Y, Asayama K, Ohkubo T, Izawa S, et al. A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: the Saku study. Metabolism. 2018;82:56–64.

    Article  CAS  Google Scholar 

  4. Morimoto A, Tatsumi Y, Deura K, Mizuno S, Ohno Y, Miyamatsu N, et al. Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku Study. Diabetologia. 2013;56:1671–9.

    Article  CAS  PubMed  Google Scholar 

  5. Tatsumi Y, Morimoto A, Miyamatsu N, Noda M, Ohno Y, Deura K. Effect of body mass index on insulin secretion or sensitivity and diabetes. Am J Prev Med. 2015;48:128–35.

    Article  PubMed  Google Scholar 

  6. Kashiwagi A, Kasuga M, Araki E, et al. Committee on the standardization of diabetes mellitus-related laboratory testing of Japan Diabetes Society. International clinical harmonization of glycated hemoglobin in Japan: from Japan diabetes society to national glycohemoglobin standardization program values. J Diabetes Invest. 2012;3:39–40.

    Article  Google Scholar 

  7. Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res. 2014;37:253–390.

    Article  CAS  PubMed  Google Scholar 

  8. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, et al. Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan-2012 version. J Atheroscler Thromb. 2013;20:517–23.

    Article  PubMed  Google Scholar 

  9. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med. 1995;152:1107–36.

    Article  Google Scholar 

  10. Kubota M, Kobayashi H, Quanjer PH, Omori H, Tatsumi K, Kanazawa M, Clinical Pulmonary Functions Committee of the Japanese Respiratory Society. Reference values for spirometry, including vital capacity, in Japanese adults calculated with the LMS method and compared with previous values. Respir Investig. 2014;52:242–50.

    Article  PubMed  Google Scholar 

  11. Scarlata S, Fimognari FL, Cesari M, et al. Lung function changes in older people with metabolic syndrome and diabetes. Geriatr Gerontol Int. 2013;13:894–900.

    Article  PubMed  Google Scholar 

  12. Ford ES, Cunningham TJ, Mercado CI. Lung function and metabolic syndrome: findings of National Health and Nutrition Examination Survey 2007–2010. J Diabetes. 2014;6:603–13.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wanke T, Formanek D, Auinger M, Popp W, Zwick H, Irsigler K. Inspiratory muscle performance and pulmonary function changes in insulin-dependent diabetes mellitus. Am Rev Respir Dis. 1991;143:97–100.

    Article  CAS  PubMed  Google Scholar 

  14. Meo SA, Al-Drees AM, Arif M, Shah FA, Al-Rubean K. Assessment of respiratory muscles endurance in diabetic patients. Saudi Med J. 2006;27:223–6.

    PubMed  Google Scholar 

  15. Fuso L, Pitocco D, Longobardi A, Zaccardi F, Contu C, Pozzuto C, et al. Reduced respiratory muscle strength and endurance in type 2 diabetes mellitus. Diabetes Metab Res Rev. 2012;28:370–5.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by a Grant-in-Aid from the Japan Society for the Promotion of Science Fellows (JSPS KAKENHI Grant number JP16J08351). We thank all the researchers and medical staff of Saku Central Hospital for undertaking the medical examinations. We sincerely thank T Nagao (Shiga University of Medical Science, Otsu, Japan) for his advice on this manuscript.

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Authors and Affiliations

  1. Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Nao Sonoda & Yuko Ohno

  2. Department of Fundamental Nursing, Graduate School of Nursing, Osaka Prefecture University, Habikino, Japan

    Akiko Morimoto

  3. Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan

    Yukako Tatsumi, Kei Asayama & Takayoshi Ohkubo

  4. Saku Central Hospital, Saku, Japan

    Satoshi Izawa

Authors
  1. Nao Sonoda
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  2. Akiko Morimoto
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  3. Yukako Tatsumi
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  4. Kei Asayama
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  5. Takayoshi Ohkubo
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  6. Satoshi Izawa
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  7. Yuko Ohno
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Contributions

NS participated in the design of the study, analyzed data and wrote the manuscript. AM, YT, KA, TO, and YO participated in the design of the study, and contributed to the writing and editing of the manuscript. SI collected data, and contributed to the writing and editing of the manuscript. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Nao Sonoda.

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Conflict of interest

The authors declare that they have no conflict of interest.

Human rights and animal participants

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or substitute for it was obtained from all patients for being included in the study.

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Sonoda, N., Morimoto, A., Tatsumi, Y. et al. The association between glycemic control and lung function impairment in individuals with diabetes: the Saku study. Diabetol Int 10, 213–218 (2019). https://doi.org/10.1007/s13340-018-0382-y

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  • DOI: https://doi.org/10.1007/s13340-018-0382-y

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